High levels of enhanced reactivation of herpes simplex virus in skin fibroblasts from various hereditary cancer-prone syndromes

The dose response of the enhanced reactivation (ER) of herpes simplex virus type 1 has been studied in UV-irradiated normal human skin fibroblasts and fibroblasts from the following hereditary cancer-prone syndromes: retinoblastoma, aniridia, polyposis coli, neurofibromatosis type 1 and 2, dysplasti...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1992, Vol.52 (1), p.53-57
Main Authors: ABRAHAMS, P. J, HOUWELING, A, VAN DER EB, A. J
Format: Article
Language:English
Subjects:
Aniridia - microbiology
Biological and medical sciences
Bloom Syndrome - microbiology
Dose-Response Relationship, Radiation
Dysplastic Nevus Syndrome - microbiology
Fibroblasts - microbiology
Fibroblasts - radiation effects
Humans
Medical sciences
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplastic Syndromes, Hereditary - microbiology
Retinoblastoma - microbiology
Simplexvirus - growth & development
SOS Response (Genetics)
Tumors
Virus Activation
von Hippel-Lindau Disease - microbiology
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Summary:The dose response of the enhanced reactivation (ER) of herpes simplex virus type 1 has been studied in UV-irradiated normal human skin fibroblasts and fibroblasts from the following hereditary cancer-prone syndromes: retinoblastoma, aniridia, polyposis coli, neurofibromatosis type 1 and 2, dysplastic nevus syndrome, Von Hippel-Lindau syndrome, multiple endocrine neoplasia type 2, and Bloom's syndrome. Surprisingly, much higher levels of ER were observed in all these genetically heterogeneous hereditary disorders than in normal human skin fibroblasts. These results suggest that loss of one allele of putative tumor suppressor genes may activate cellular processes that result in the induction of the ER response, and they support our previous observation suggesting that ER may somehow be related to the process of carcinogenesis (P. J. Abrahams et al., Cancer Res., 48: 6054-6057, 1988).
ISSN:0008-5472
1538-7445