Clinicopathologic and molecular analysis of disseminated appendiceal mucinous neoplasms: identification of factors predicting survival and proposed criteria for a three-tiered assessment of tumor grade

Previous studies have demonstrated that the prognosis of disseminated mucinous appendiceal neoplasms is highly dependent upon tumor grade. Reflecting this, the 7th edition of the American Joint Committee on Cancer (AJCC) staging system now incorporates a three-tier grading system for prognostic stag...

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Bibliographic Details
Published in:Modern pathology 2014-11, Vol.27 (11), p.1521-1539
Main Authors: Davison, Jon M, Choudry, Haroon A, Pingpank, James F, Ahrendt, Steven A, Holtzman, Matthew P, Zureikat, Amer H, Zeh, Herbert J, Ramalingam, Lekshmi, Zhu, Benjamin, Nikiforova, Marina, Bartlett, David L, Pai, Reetesh K
Format: Article
Language:English
Subjects:
692/699/67/1504/1885
692/700/139/1677
692/700/139/422
Adenocarcinoma, Mucinous - classification
Adenocarcinoma, Mucinous - diagnosis
Adenocarcinoma, Mucinous - genetics
Adenocarcinoma, Mucinous - mortality
Adenocarcinoma, Mucinous - secondary
Appendiceal Neoplasms - classification
Appendiceal Neoplasms - diagnosis
Appendiceal Neoplasms - genetics
Appendiceal Neoplasms - mortality
Appendiceal Neoplasms - pathology
appendix
Biomarkers, Tumor - genetics
Biopsy
Cancer
Carcinoma, Signet Ring Cell - classification
Carcinoma, Signet Ring Cell - diagnosis
Carcinoma, Signet Ring Cell - genetics
Carcinoma, Signet Ring Cell - mortality
Carcinoma, Signet Ring Cell - secondary
Chemotherapy
Chi-Square Distribution
Classification
disseminated peritoneal adenomucinosis
DNA Mutational Analysis
Humans
Kaplan-Meier Estimate
Laboratory Medicine
Loss of Heterozygosity
low-grade mucinous neoplasm
Medical prognosis
Medicine
Medicine & Public Health
Molecular Diagnostic Techniques
mucinous adenocarcinoma
Multivariate Analysis
Mutation
Neoplasm Grading - methods
Neoplasm Invasiveness
original-article
Pathology
Pennsylvania
peritoneal mucinous carcinomatosis
Polymerase Chain Reaction
Predictive Value of Tests
Proportional Hazards Models
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins p21(ras)
pseudomyxoma peritonei
ras Proteins - genetics
Risk Assessment
Risk Factors
Terminology
Tumors
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Summary:Previous studies have demonstrated that the prognosis of disseminated mucinous appendiceal neoplasms is highly dependent upon tumor grade. Reflecting this, the 7th edition of the American Joint Committee on Cancer (AJCC) staging system now incorporates a three-tier grading system for prognostic staging of mucinous appendiceal tumors. However, the grading criteria are not well described. In order to address this issue, we evaluated clinicopathologic and molecular features of 219 cases from 151 patients with widely disseminated appendiceal mucinous neoplasia treated at our institution between 2004 and 2012. We identified histologic features that were associated with worse overall survival on univariate analysis: destructive invasion, high cytologic grade, high tumor cellularity, angiolymphatic invasion, perineural invasion, and signet ring cell component (all with P
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.2014.37