Adaptations of aortic and pulmonary artery flow parameters measured by phase-contrast magnetic resonance angiography during supine aerobic exercise

• Published in: European journal of applied physiology 2014-05, Vol.114 (5), p.1013-1023
• Main Authors: Pieles, Guido E., Szantho, Gergely, Rodrigues, Jonathan C. L., Lawton, Christopher B., Stuart, A. Graham, Bucciarelli-Ducci, Chiara, Turner, Mark S., Williams, Craig A., Tulloh, Robert M. R., Hamilton, Mark C. K.
• Format: Article
• Language: English
• Subjects: Adaptation, Physiological; Adult; Aerobics; Aorta, Thoracic - physiology; Aortography - instrumentation; Aortography - methods; Biomedical and Life Sciences; Biomedicine; Coronary vessels; Exercise; Female; Heart rate; Hemodynamics; Human Physiology; Humans; Leg - physiology; Magnetic Resonance Angiography - instrumentation; Magnetic Resonance Angiography - methods; Magnetic resonance imaging; Male; Medical imaging; Occupational Medicine/Industrial Medicine; Original Article; Physical fitness; Physiology; Pilot projects; Pulmonary arteries; Pulmonary Artery - diagnostic imaging; Pulmonary Artery - physiology; Sports Medicine; Supine Position; Veins & arteries; Velocity
• ISSN: 1439-6319; 1439-6327
• DOI: 10.1007/s00421-014-2833-x

Purpose Increased oxygen uptake and utilisation during exercise depend on adequate adaptations of systemic and pulmonary vasculature. Recent advances in magnetic resonance imaging techniques allow for direct quantification of aortic and pulmonary blood flow using phase-contrast magnetic resonance angiography (PCMRA). This pilot study tested quantification of aortic and pulmonary haemodynamic adaptations to moderate aerobic supine leg exercise using PCMRA. Methods Nine adult healthy volunteers underwent pulse gated free breathing PCMRA while performing heart rate targeted aerobic lower limb exercise. Flow was assessed in mid ascending and mid descending thoracic aorta (AO) and main pulmonary artery (MPA) during exercise at 180 % of individual resting heart rate. Flow sequence analysis was performed by experienced operators using commercial offline software (Argus, Siemens Medical Systems). Results Exercise related increase in HR (rest: 69 ± 10 b min −1 , exercise: 120 ± 13 b min −1 ) resulted in cardiac output increase (from 6.5 ± 1.4 to 12.5 ± 1.8 L min −1 ). At exercise, ascending aorta systolic peak velocity increased from 89 ± 14 to 122 ± 34 cm s −1 ( p  = 0.016), descending thoracic aorta systolic peak velocity increased from 104 ± 14 to 144 ± 33 cm s −1 ( p  = 0.004), MPA systolic peak velocity from 86 ± 18 to 140 ± 48 cm s −1 ( p  = 0.007), ascending aorta systolic peak flow rate from 415 ± 83 to 550 ± 135 mL s −1 ( p  = 0.002), descending thoracic aorta systolic peak flow rate from 264 ± 70 to 351 ± 82 mL s −1 ( p  = 0.004) and MPA systolic peak flow rate from 410 ± 80 to 577 ± 180 mL s −1 ( p  = 0.006). Conclusion Quantitative blood flow and velocity analysis during exercise using PCMRA is feasible and detected a steep exercise flow and velocity increase in the aorta and MPA. Exercise PCMRA can serve as a research and clinical tool to help quantify exercise blood flow adaptations in health and disease and investigate patho-physiological mechanisms in cardio-pulmonary disease.