Use of screening to recruitment ratios as a tool for planning and implementing spinal cord injury rehabilitation research

• Published in: Spinal cord 2014-10, Vol.52 (10), p.764-768
• Main Authors: Craven, B C, Balioussis, C, Hitzig, S L, Moore, C, Verrier, M C, Giangregorio, L M, Popovic, M R
• Format: Article
• Language: English
• Subjects: 692/308/575; Adult; Anatomy; Biomedical and Life Sciences; Biomedical Research - methods; Biomedicine; Clinical Trials as Topic - methods; Female; Human Physiology; Humans; Male; Middle Aged; Neurochemistry; Neuropsychology; Neurosciences; Ontario; original-article; Patient Selection; Research Design - standards; Spinal Cord Injuries - diagnosis; Spinal Cord Injuries - therapy
• ISSN: 1362-4393; 1476-5624
• DOI: 10.1038/sc.2014.126

Study design: Descriptive report. Objectives: To describe screening to recruitment (S:R) ratios and discuss their use for planning and implementing research among individuals with spinal cord injury (SCI). Setting: Toronto, Ontario, Canada. Methods: We calculated S:R ratios for SCI research by study methodology and nature of the exposure/intervention for 25 studies previously conducted in a tertiary SCI rehabilitation facility. Study methodologies included ten randomized controlled trials (RCTs), nine cohort studies and six panel studies. Exposures included seven rehabilitation interventions, and three drug studies, ten telephone interviews/chart abstractions (TI/CA) and five surveys. A S:R ratio was calculated for each study methodology, and exposure type, by dividing the number of consenting individuals who underwent screening by the number of eligible recruited participants enrolled in the study. Results: In terms of design, RCTs had the highest median S:R ratio (3:1), followed by cohort studies (2:1) and panel studies (2:1). In terms of intervention type, drug studies had the largest median S:R ratio (5:1), followed in descending order by rehabilitation studies (2:1), TI/CAs studies (2:1) and surveys (2:1). Conclusions: Reported S:R ratios varied substantially with study methodology and the associated study intervention exposure. Awareness of S:R ratios may assist researchers in estimating recruitment timelines, personnel needs and study budgets for a required sample size based on the planned study methodology and intended study exposure. We advocate for the routine reporting of S:R ratios to inform the success of future SCI research.