Selective upregulation of p66-Shc gene expression in the liver and brain of aged rats

Abstract The phosphotyrosine signaling followed by various receptor activations conforms a unique signaling platform during metazoan evolution, and is crucial for animal development, maturation, and aging. Shc is the most versatile bipartite phosphotyrosine signal adaptor harboring phosphotrosine-bi...

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Bibliographic Details
Published in:Archives of gerontology and geriatrics 2012-11, Vol.55 (3), p.744-748
Main Authors: Sone, Kiyoaki, Mori, Mari, Mori, Nozomu
Format: Article
Language:English
Subjects:
Adapter
Ageing
Aging - genetics
Animals
Anti-aging
Brain
Brain - metabolism
Gene Expression Regulation
Genes
Internal Medicine
Liver
Liver - metabolism
Longevity
Male
Metazoa
Phosphotyrosine
Rats
Rats, Inbred F344
Shc Signaling Adaptor Proteins - genetics
Signal transduction
Src Homology 2 Domain-Containing, Transforming Protein 1
Transcriptome
Up-Regulation
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Summary:Abstract The phosphotyrosine signaling followed by various receptor activations conforms a unique signaling platform during metazoan evolution, and is crucial for animal development, maturation, and aging. Shc is the most versatile bipartite phosphotyrosine signal adaptor harboring phosphotrosine-biding (PTB) and Src-homology2 (SH2) domains. Among the Shc adaptor family members, p66-Shc is of potential interest in aging studies, since its deletion in mice resulted in a longer lifespan and/or higher quality of life in later stages of life. However, a few studies have examined the gene expression profiles of p66-Shc in aging tissues. Here, we quantified the expression levels of transcripts of Shc-related isoforms in the liver and brain of young adult, middle-aged, and aged rats, and found that p66-Shc gene expression is specifically up-regulated in the aged liver and brain. In the aged liver tissue, p66-Shc expression was also evident at the protein level, and accumulated in the soluble fraction of the aged tissue. These results indicate that p66-Shc is not only related to animal longevity but also affected during aging, and thus the repression of p66-Shc could become a potential target for an anti-aging strategy.
ISSN:0167-4943
1872-6976
DOI:10.1016/j.archger.2011.11.001