Species-specific alteration of hepatic glucose 6-phosphate dehydrogenase activity with coplanar polychlorinated biphenyl: Evidence for an Ah-receptor - linked mechanism

• Published in: Chemosphere (Oxford) 1997-09, Vol.35 (5), p.951-958
• Main Authors: Hori, Miho, Kondo, Hiroshi, Ariyoshi, Noritaka, Yamada, Hideyuki, Oguri, Kazuta
• Format: Article
• Language: English
• Subjects: 3,3′,4,4′5-Pentachlorobiphenyl (PCB 126); Animals; Arylhydrocarbon receptor; Biological and medical sciences; C57BL mice; Chemical and industrial products toxicology. Toxic occupational diseases; DBA mice; Dose-Response Relationship, Drug; Enzyme Induction; Glucose 6-phosphate dehydrogenase; Glucosephosphate Dehydrogenase - biosynthesis; Guinea Pigs; Liver - drug effects; Liver - enzymology; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Polychlorinated Biphenyls - toxicity; Rats; Rats, Wistar; Receptors, Aryl Hydrocarbon - drug effects; Receptors, Aryl Hydrocarbon - metabolism; Species Specificity; Toxicology; Various organic compounds
• ISSN: 0045-6535; 1879-1298
• DOI: 10.1016/S0045-6535(97)00181-1

We examined the in vivo effect of a highly toxic coplanar polychlorinated biphenyl (PCB) on the hepatic activity of glucose 6-phosphate dehydrogenase (G6PDH) in aryl hydrocarbon (Ah)-responsive (C57/BL) and -less-responsive (DBA) strains of mice. The activity in the C57BL strain was moderately increased by 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) in a dose dependent manner. However, this was not observed in DBA mice although greater doses were injected. 2,2′,5,5′-Tetrachlorobiphenyl (PCB 52) with a non-planar structure did not increase G6PDH activity. The increase in G6PDH activity with PCB 126 was also seen in rats, but not in guinea pigs. The activity in the latter species was decreased rather than increased. These results suggest that the induction of hepatic G6PDH by coplanar PCB is mediated by a mechanism involving the Ah receptor, and the response was highly species-specific.