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Co-infection with several HCV genotypes enhances liver damage in patients with chronic hepatitis C

Hepatitis C virus (HCV) has been classified into at least nine major genotypes, based on the nucleotide sequence variation. The influence of each HCV variant on the natural course of liver disease remains to be elucidated. As part of a multicentre Spanish study which analysed the rate of response to...

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Bibliographic Details
Published in:The Journal of infection 1997-09, Vol.35 (2), p.202-203
Main Authors: Soriano, V., Bravo, R., García-Samaniego, J., Castilla, J., Castro, A., Carballo, E., González-Anglada, I., Moreno, A.
Format: Article
Language:English
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Summary:Hepatitis C virus (HCV) has been classified into at least nine major genotypes, based on the nucleotide sequence variation. The influence of each HCV variant on the natural course of liver disease remains to be elucidated. As part of a multicentre Spanish study which analysed the rate of response to alpha interferon in patients with chronic hepatitis C, we had the opportunity to investigate the role of HCV genotypes in liver damage. Liver histology was scored using the Knodell's index in 78 patients with chronic hepatitis C, defined on the basis of persistently elevated alanine aminotransferase levels, presence of serum anti-HCV antibodies, and histological findings of chronic hepatitis. In conclusion, our results suggest that both HCV 1b genotype and co-infection with several HCV genotypes seem to be associated with a more severe liver histology in patients with chronic hepatitis C, and thus should be considered in the management of HCV-infected patients.
ISSN:0163-4453
1532-2742
DOI:10.1016/S0163-4453(97)92139-3