Effect of Iron Supplementation on the Expression of Hypoxia-Inducible Factor and Antioxidant Status in Rats Exposed to High-Altitude Hypoxia Environment

Iron and oxygen are essential substance for cellular activity in body tissues. Hypoxia-inducible factors (HIFs) can respond to available oxygen changes in the cellular environment and regulate the transcription of a series of target genes. The study was conducted to investigate the effects of iron s...

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Bibliographic Details
Published in:Biological trace element research 2014-12, Vol.162 (1-3), p.142-152
Main Authors: Xu, Chunlan, Dong, Chen, Xu, Cuicui, Han, Tiaotiao, Bao, Sheng, Gao, Xiaobo
Format: Article
Language:English
Subjects:
Altitude
Animals
Antioxidants
Antioxidants - metabolism
Biochemistry
Biomedical and Life Sciences
Biotechnology
Body weight
Enzymatic activity
Erythropoietin - blood
Ferrous Compounds - therapeutic use
Hypoxia
Hypoxia - drug therapy
Hypoxia-Inducible Factor 1, alpha Subunit - genetics
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Immunohistochemistry
Iron
Life Sciences
Liver
Liver - metabolism
Male
Malondialdehyde - metabolism
Nutrition
Oncology
Protein expression
Rats
Rats, Sprague-Dawley
RNA, Messenger - genetics
Rodents
Transferrin - genetics
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Summary:Iron and oxygen are essential substance for cellular activity in body tissues. Hypoxia-inducible factors (HIFs) can respond to available oxygen changes in the cellular environment and regulate the transcription of a series of target genes. The study was conducted to investigate the effects of iron supplementation on the expression of hypoxia-inducible factor-1 alpha (HIF-1α) and antioxidant status in rats exposed to high-altitude hypoxia environment. Forty rats were divided into control (CON), hypobaric hypoxia (HH), and hypobaric hypoxia plus ferrous sulfate (FeSO 4 ) (9.93 mg/kg body weight (BW)/day) (HFS) and hypobaric hypoxia plus iron glycinate chelate (Fe-Gly) (11.76 mg/kg BW/day) (HFG) groups. Results showed that Fe-Gly effectively alleviated weight loss and intestinal mucosa damage induced by hypobaric hypoxia, whereas FeSO 4 aggravated hypobaric hypoxia-induced weight loss, liver enlargement, spleen atrophy, and intestinal damage. Iron supplementation decreased liver superoxide dismutase (T-SOD) and catalase (CAT) activity ( P  
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-014-0166-6