Mucosally transmitted feline immunodeficiency virus induces a CD8 super(+) antiviral response that correlates with reduction of cell-associated virus

Intravaginal inoculation of cats with feline immunodeficiency virus (FIV) results in acute systemic infection accompanied by a strong CD8 super(+) immune response that inhibits viral replication. CD8 super(+) anti-FIV activity, revealed by increased FIV replication in peripheral blood mononuclear ce...

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Bibliographic Details
Published in:The Journal of infectious diseases 1998-01, Vol.177 (1), p.18-25
Main Authors: Bucci, J G, English, R V, Jordan, H L, Childers, T A, Tompkins, M B, Tompkins, WAF
Format: Article
Language:English
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Summary:Intravaginal inoculation of cats with feline immunodeficiency virus (FIV) results in acute systemic infection accompanied by a strong CD8 super(+) immune response that inhibits viral replication. CD8 super(+) anti-FIV activity, revealed by increased FIV replication in peripheral blood mononuclear cells (PBMC) depleted of CD8 super(+) lymphocytes, was detected by 6 weeks after inoculation and correlated with reduced PBMC-associated virus at 12, 16, and 32 weeks after inoculation. Some cats with strong CD8 super(+) anti-FIV activity during acute infection did not seroconvert and yielded no evidence of FIV infection at later times. These data suggest that CD8 super(+) immunity may play a major role in eliminating virus during primary transmucosal FIV infection and may down-regulate viral replication during asymptomatic infection.
ISSN:0022-1899