The hydroxylation of some 13α-methylsteroids by Cephalosporium aphidicola

The fungus, Cephalosporium aphidicola, has been shown to hydroxylate 5α,13α-androstan-3,17-dione and the 3β-alcohol at the C-1α and C-7α positions, whereas the corresponding compounds in the normal 13β-methyl series are hydroxylated at the C-11α and C-14α positions. Both series were hydroxylated at...

Full description

Saved in:
Bibliographic Details
Published in:Phytochemistry (Oxford) 1997-07, Vol.45 (5), p.951-956
Main Authors: Boynton, Juliette, Hanson, James R., Hunter, A.Christy
Format: Article
Language:English
Subjects:
13α-methylsteroids
androstanes
biochemical pathways
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Cephalosporium
Cephalosporium aphidicola
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
microbiological hydroxylation
nuclear magnetic resonance spectroscopy
steroid metabolism
transformation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The fungus, Cephalosporium aphidicola, has been shown to hydroxylate 5α,13α-androstan-3,17-dione and the 3β-alcohol at the C-1α and C-7α positions, whereas the corresponding compounds in the normal 13β-methyl series are hydroxylated at the C-11α and C-14α positions. Both series were hydroxylated at the 5α-position. There was some epimerization of the axial 3α-alcohols to the equatorial 3β-epimers. © 1997 Elsevier Science Ltd. All rights reserved
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(97)00103-9