Mechanical loading leads to osteoarthritis-like changes in the hypofunctional temporomandibular joint in rats

Highlights • TMJ hypofunction leads to OA-like changes under mechanical loading. • Masticatory stimulation in growing period is essential for normal TMJ development. • Mechanical loading arises cell-free areas in hypofunctional TMJ chondrocyte.

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Bibliographic Details
Published in:Archives of oral biology 2014-12, Vol.59 (12), p.1368-1376
Main Authors: Ikeda, Yuhei, Yonemitsu, Ikuo, Takei, Maki, Shibata, Shunichi, Ono, Takashi
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Dental Stress Analysis
Dentistry
Growth
Male
Mastication - physiology
Matrix Metalloproteinase 13 - metabolism
Matrix metalloproteinase-13
Mechanical loading
Osteoarthritis - diagnostic imaging
Osteoarthritis - etiology
Osteoarthritis - physiopathology
Rats
Rats, Wistar
Stress, Mechanical
Temporomandibular Joint - diagnostic imaging
Temporomandibular Joint - physiopathology
Temporomandibular joint hypofunction
TMJ-osteoarthritis
X-Ray Microtomography
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Description
Summary:Highlights • TMJ hypofunction leads to OA-like changes under mechanical loading. • Masticatory stimulation in growing period is essential for normal TMJ development. • Mechanical loading arises cell-free areas in hypofunctional TMJ chondrocyte.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2014.08.010