The association of inflammatory markers with cerebral vasoreactivity and carotid atherosclerosis in transient ischaemic attack

Inflammatory mediators have an important role in the pathogenesis of stroke. Increased activity of inflammatory mediators initiates the development of atherosclerosis independently of other risk factors, thus compromising brain microcirculation and causing transient ischaemic attack (TIA). The aim o...

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Bibliographic Details
Published in:Clinical biochemistry 2014-11, Vol.47 (16-17), p.182-186
Main Authors: Martinic-Popovic, Irena, Simundic, Ana-Maria, Dukic, Lora, Lovrencic-Huzjan, Arijana, Popovic, Alek, Seric, Vesna, Basic-Kes, Vanja, Demarin, Vida
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers - blood
C-Reactive Protein - metabolism
Carotid Artery Diseases - blood
Carotid Artery Diseases - immunology
Carotid Intima-Media Thickness
CRP
Female
Humans
ICAM-1
IL-6
Inflammation
Inflammation - blood
Inflammation - immunology
Intercellular Adhesion Molecule-1 - blood
Interleukin-6 - blood
Ischemic Attack, Transient - blood
Ischemic Attack, Transient - immunology
Male
Middle Aged
Transient ischaemic attack
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Summary:Inflammatory mediators have an important role in the pathogenesis of stroke. Increased activity of inflammatory mediators initiates the development of atherosclerosis independently of other risk factors, thus compromising brain microcirculation and causing transient ischaemic attack (TIA). The aim of our study was to evaluate the relationship between serum level of cellular adhesion molecules (ICAM-1), interleukin-6 (IL-6) and C-reactive protein (CRP) with carotid intima–media thickness (IMT) and breath-holding index (BHI) in subjects with transient ischaemic attack. We also aimed to assess the difference of those markers between TIA patients and disease-free control individuals. The study included 45 TIA patients and 36 disease-free controls matched for age, gender and vascular risk profile. The degree of carotid atherosclerosis was assessed by colour Doppler with measurements of carotid IMT. Transcranial Doppler (TCD) ultrasound was performed in order to assess BHI. IMT, TCD, BHI and serum concentrations of ICAM-1, IL-6, and CRP were measured for all study subjects. Inflammatory markers IL-6, ICAM-1 and CRP were significantly higher in TIA patients than in disease-free controls (P
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2014.07.010