Independent association of obstructive sleep apnea with left ventricular geometry and systolic function in resistant hypertension: the RESIST-POL study

Abstract Objective We investigated the impact of obstructive sleep apnea (OSA) and night blood pressure (BP) on left ventricular geometry and systolic function in patients with resistant hypertension (RHTN). Methods and Results Data from 155 patients with RHTN were analyzed. All patients underwent b...

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Bibliographic Details
Published in:Sleep medicine 2014-11, Vol.15 (11), p.1302-1308
Main Authors: Dobrowolski, Piotr, Klisiewicz, Anna, Florczak, Elżbieta, Prejbisz, Aleksander, Bieleń, Przemysław, Śliwiński, Paweł, Kabat, Marek, Rybicka, Justyna, Topór-Mądry, Roman, Januszewicz, Andrzej, Hoffman, Piotr
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Pressure - physiology
Echocardiography
Female
Heart Ventricles - pathology
Heart Ventricles - physiopathology
Humans
Hypertension
Hypertension - chemically induced
Hypertension - physiopathology
Left ventricular geometry
Left ventricular systolic function
Male
Metabolic Syndrome - complications
Metabolic Syndrome - physiopathology
Middle Aged
Neurology
Obstructive sleep apnea
Polysomnography
Sleep Apnea, Obstructive - complications
Sleep Apnea, Obstructive - physiopathology
Sleep Medicine
Stroke Volume - physiology
Systole - physiology
Ventricular Function, Left - physiology
Young Adult
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Summary:Abstract Objective We investigated the impact of obstructive sleep apnea (OSA) and night blood pressure (BP) on left ventricular geometry and systolic function in patients with resistant hypertension (RHTN). Methods and Results Data from 155 patients with RHTN were analyzed. All patients underwent biochemical evaluations, ambulatory blood pressure monitoring (ABPM), and polysomnography. Left ventricular mass index (LVMI), relative wall thickness (RWT), left ventricular ejection fraction (LVEF), midwall fractional shortening (mwFS) and global longitudinal strain (GLS) were measured. Patients were divided into four groups based on the presence of metabolic syndrome (MS) and OSA: group 1: OSA(−), MS(−) [ n  = 42]; group 2: OSA(+), MS(−) [ n  = 14]; group 3: OSA(–), MS(+) [ n  = 46]; and group 4: OSA(+), MS(+) [ n  = 53]. In group 3 and 4 concentric geometry was present in 53.2% and 79.6% respectively ( P  = 0.004). There were no differences in LVEF between groups. Group 3 and 4 had lower mwFS as compared with group 1 (16.40 ± 1.9 and 15.38 ± 2.2 vs 17.44 ± 1.9; P  
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2014.06.015