The adverse effects of preoperative cholangitis on the outcome of portal vein embolization and subsequent major hepatectomies

Background The presence of cholangitis has been shown to impair liver regeneration capacity after major hepatectomy in a rat cholangitis model. It is unclear, however, whether the presence of cholangitis has any impact on liver generation in clinical settings. Objective To determine the effects of p...

Full description

Saved in:
Bibliographic Details
Published in:Surgery 2014-11, Vol.156 (5), p.1190-1196
Main Authors: Yokoyama, Yukihiro, MD, Ebata, Tomoki, MD, Igami, Tsuyoshi, MD, Sugawara, Gen, MD, Mizuno, Takashi, MD, Nagino, Masato, MD
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cholangitis - physiopathology
Embolization, Therapeutic
Female
Hepatectomy - mortality
Humans
Japan - epidemiology
Liver Regeneration
Male
Middle Aged
Portal Vein
Postoperative Period
Retrospective Studies
Surgery
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The presence of cholangitis has been shown to impair liver regeneration capacity after major hepatectomy in a rat cholangitis model. It is unclear, however, whether the presence of cholangitis has any impact on liver generation in clinical settings. Objective To determine the effects of preoperative cholangitis on hepatic regeneration rates after preoperative portal vein embolizations (PVEs) and postoperative courses after major hepatectomies in humans. Methods From 1991 to 2012, 450 patients underwent preoperative PVEs and subsequent major hepatectomies. Among them, 72 patients (16.0%) had preoperative cholangitis. The volume change of the nonembolized lobe after PVE and the postoperative outcomes after a major hepatectomy were compared between cholangitis and noncholangitis groups. Results The average volume increase in the nonembolized lobe after PVE was almost identical in both the cholangitis (10.0%) and noncholangitis (9.5%) groups. The average term required to acquire institutional safety criteria, however, was longer in the cholangitis group (24.3 days) compared with the noncholangitis group (18.3 days) ( P  
ISSN:0039-6060
1532-7361
DOI:10.1016/j.surg.2014.04.036