Physical function and quality of life in frail and/or elderly patients with metastatic colorectal cancer treated with capecitabine and bevacizumab: An exploratory analysis

• Published in: Journal of geriatric oncology 2014-10, Vol.5 (4), p.368-375
• Main Authors: Ward, Peter, Hecht, J. Randolph, Wang, He-Jing, Dichmann, Richard, Liem, Andre K.D, Chan, David, Patel, Ravi, Hu, Edward H.L, Tchekmedyian, Neres S, Wainberg, Zev A, Naeim, Arash
• Format: Article
• Language: English
• Subjects: Activities of Daily Living; Aged; Aged, 80 and over; Angiogenesis Inhibitors - therapeutic use; Antibodies, Monoclonal, Humanized - therapeutic use; Antimetabolites, Antineoplastic - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Bevacizumab; California - epidemiology; Capecitabine; Colon cancer; Colorectal cancer; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - pathology; Deoxycytidine - analogs & derivatives; Deoxycytidine - therapeutic use; Disease-Free Survival; Elderly; Female; Fluorouracil - analogs & derivatives; Fluorouracil - therapeutic use; Frail; Frail Elderly - statistics & numerical data; Geriatric Assessment - methods; Geriatric Assessment - statistics & numerical data; Health Status; Hematology, Oncology and Palliative Medicine; Humans; Internal Medicine; Male; Metastatic; Middle Aged; Performance status; Physical function; Prospective Studies; Quality of Life; Surveys and Questionnaires; Toxicity
• ISSN: 1879-4068; 1879-4076
• DOI: 10.1016/j.jgo.2014.05.002

Abstract Objectives Optimal treatment strategies in frail and/or elderly patients with metastatic colorectal cancer have not been well defined. Using data from a prospective, phase II study of elderly patients with metastatic colorectal cancer treated with bevacizumab and capecitabine, we explored the differences in functional measure and quality of life (QoL) between patients with ECOG performance status (PS) 1 and 2. Materials and Methods Geriatric functional measures included patient reported limitations in ADLs and IADLs, ECOG PS, 3-item recall, hearing acuity, and the “Get up and Go” test. QoL was assessed by means of the FACT-C questionnaire and the EQ-5D questionnaire. The prognostic impact of baseline characteristics on survival was studied using univariate Cox regression analysis. Results The majority (62%) of the 45 patients had an ECOG PS of 2. The ECOG PS 2 group had more limitations in IADLs, lower baseline QoL, and a lower patient-rated health score. For all participants, QoL significantly improved from baseline to the start of cycle 2 (FACT-C: 99.9 vs. 105.4, p = 0.01) and did not deteriorate when baseline scores were compared to when participants went off study (FACT-C: 99.9 vs. 98.6, p = 0.59). In the Cox-regression analysis, a positive “Get up and Go” test was prognostic for improved survival (HR = 0.31, p = 0.01). Conclusion There is significant heterogeneity in functional measures and quality of life among elderly patients with metastatic colorectal cancer with ECOG PS 1 and 2. The “Get up and Go” test may be a useful prognostic indicator for survival in this population.