Phenolic compounds from sandpaper (ficus exasperata) leaf inhibits angiotensin 1 converting enzyme in high cholesterol diet fed rats

Sandpaper [Ficus exasperata Vahl (Moraceae)] leaf has been reportedly used in folklore for the management/treatment of cardiovascular diseases with little/or no scientific basis for their action. This study sought to investigate the effect of dietary supplementation of sandpaper leaf on angiotensin-...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2014-11, Vol.157, p.119-125
Main Authors: Oboh, G., Akinyemi, A.J., Osanyinlusi, F.R., Ademiluyi, A.O., Boligon, A.A., Athayde, M.L.
Format: Article
Language:English
Subjects:
ACE
Angiotensin-Converting Enzyme Inhibitors - administration & dosage
Angiotensin-Converting Enzyme Inhibitors - isolation & purification
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Animals
Cholesterol, Dietary - administration & dosage
Chromatography, High Pressure Liquid - methods
Dietary Supplements
Dose-Response Relationship, Drug
Ficus - chemistry
Hypercholesterolemia
Hypercholesterolemia - drug therapy
Inhibitory Concentration 50
Lipids - blood
Medicine, Traditional
Peptidyl-Dipeptidase A - drug effects
Phenolics
Phenols - administration & dosage
Phenols - isolation & purification
Phenols - pharmacology
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Leaves
Rats
Rats, Wistar
Sandpaper leaf
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Summary:Sandpaper [Ficus exasperata Vahl (Moraceae)] leaf has been reportedly used in folklore for the management/treatment of cardiovascular diseases with little/or no scientific basis for their action. This study sought to investigate the effect of dietary supplementation of sandpaper leaf on angiotensin-I converting enzyme (ACE) activity in hypercholesterolemia as well as the effect of their phenolic extract on this enzyme in vitro. The phenolic extract was prepared, then, the inhibitory effect of the leaf extract on ACE was determined in vitro. Thereafter, the effect of dietary supplementation of sandpaper leaf on angiotensin-I converting enzyme (ACE) activity in high cholesterol diet fed rats for 14 days was evaluated as well as some biochemical parameters. The result revealed that under in vitro condition, the phenolic extract inhibited ACE (IC50=14.7µg/mL) in a dose-dependent manner (0–10µg/mL). Feeding high cholesterol diets to rats caused a significant (P
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2014.09.029