Determinants of ART failure in HIV-1-infected adults in a semi-rural setting in Mozambique

Provision of antiretroviral therapy (ART) following a public health approach has successfully increased ART coverage and reduced HIV-1-associated mortality and transmission in resource-limited settings (RLS). Absence of HIV-1 RNA (VL) monitoring, however, may delay diagnosis of virological failure a...

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Bibliographic Details
Published in:Antiviral therapy 2014-01, Vol.19, p.A96-A96
Main Authors: Ruperez, M, Pou, C, Cedeno, S, Maculuve, S, Rodriguez, J, Letang, E, Molto, J, Macete, E, Menendez, C, Naniche, D, Paredes, R
Format: Article
Language:English
Subjects:
Human immunodeficiency virus 1
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Summary:Provision of antiretroviral therapy (ART) following a public health approach has successfully increased ART coverage and reduced HIV-1-associated mortality and transmission in resource-limited settings (RLS). Absence of HIV-1 RNA (VL) monitoring, however, may delay diagnosis of virological failure and foster the emergence of HIV drug resistance (HIVDR). In settings with limited ART monitoring options, surveillance of HIVDR and understanding of which factors are associated with loss of ART efficacy are important to guide clinical decisions and public health policies. We conducted a cross-sectional study on HIV-1-infected adults on first-line ART for at least 1 year attending routine visits in the Manhica District Hospital, a semi-rural area in southern Mozambique with no VL monitoring available. Early detection of virological failure in RLS prevents the emergence and accumulation of HIVDR. Efforts to maximize ART efficacy in this setting should include the implementation of virological monitoring, intensifying adherence support programs and strengthening schooling and education.
ISSN:1359-6535