N-Acetylaspartate and neurofilaments as biomarkers of axonal damage in patients with progressive forms of multiple sclerosis

Primary and secondary progressive forms of multiple sclerosis (PPMS and SPMS) have different pathological characteristics. However, it is unknown whether neurodegenerative mechanisms are shared. We measured cerebrospinal fluid (CSF) levels of neurofilament (Nf) light and heavy isoforms and N -acetyl...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurology 2014-12, Vol.261 (12), p.2338-2343
Main Authors: Trentini, Alessandro, Comabella, Manuel, Tintoré, Mar, Koel-Simmelink, Marleen J. A., Killestein, Joep, Roos, Birthe, Rovira, Alex, Korth, Carsten, Ottis, Philipp, Blankenstein, Marinus A., Montalban, Xavier, Bellini, Tiziana, Teunissen, Charlotte E.
Format: Article
Language:English
Subjects:
Adult
Aspartic Acid - analogs & derivatives
Aspartic Acid - cerebrospinal fluid
Axons - pathology
Biomarkers
Biomarkers - cerebrospinal fluid
Disability Evaluation
Disease Progression
Female
Follow-Up Studies
Humans
Light
Male
Medicine
Medicine & Public Health
Middle Aged
Multiple sclerosis
Multiple Sclerosis - cerebrospinal fluid
Multiple Sclerosis - pathology
Neurofilament Proteins - cerebrospinal fluid
Neurology
Neuroradiology
Neurosciences
Original Communication
Patients
Prognosis
Regression analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Primary and secondary progressive forms of multiple sclerosis (PPMS and SPMS) have different pathological characteristics. However, it is unknown whether neurodegenerative mechanisms are shared. We measured cerebrospinal fluid (CSF) levels of neurofilament (Nf) light and heavy isoforms and N -acetylaspartic acid (NAA) in 21 PP, 10 SPMS patients and 15 non-inflammatory neurological disease controls (NINDC). Biomarkers were related to Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Severity Score (MSSS) over a long period of follow-up [median (interquartile range) 9 (5.5–12.5) years] in 19 PPMS and 4 SPMS patients, and to T2 lesion load, T1 lesion load, and brain parenchymal fraction at the time of lumbar puncture. Nf light was higher in PPMS ( p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-014-7507-4