Oxidative-induction time as a measure of vitamin E concentration in ultra-high molecular weight polyethylene

A novel, sensitive method for quantifying an equivalent antioxidant concentration, specifically vitamin E (VE), in postprocessed ultra-high molecular weight polyethylene (UHMWPE) for orthopedic implants is presented. This method correlates oxidative-induction time (OIT) determined from differential...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2015-01, Vol.103 (1), p.106-115
Main Authors: Heuer, Emily G., Braithwaite, Gavin J. C., Miller, Bayen L., Spiegelberg, Stephen H., Gsell, Ray A., Rufner, Alicia S., Stark, Norman
Format: Article
Language:English
Subjects:
antioxidant
Antioxidants - chemistry
Biomedical materials
Calorimetry, Differential Scanning
differential scanning calorimetry
joint replacement
Materials research
Materials science
oxidative-induction time
polyethylene
Polyethylene - chemistry
Prostheses and Implants
Spectroscopy, Fourier Transform Infrared
Vitamin E - chemistry
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Summary:A novel, sensitive method for quantifying an equivalent antioxidant concentration, specifically vitamin E (VE), in postprocessed ultra-high molecular weight polyethylene (UHMWPE) for orthopedic implants is presented. This method correlates oxidative-induction time (OIT) determined from differential scanning calorimetry with starting VE weight percent in solvent blended samples using a nonlinear power law fit. The generated calibration curve reliably determined the equivalent VE concentration down to blended concentrations lower than 0.007 wt %, with a measurement uncertainty of 0.0009 wt %. This measurement uncertainty implies a detection limit that is significantly lower than currently achievable with the established method using Fourier transform infrared spectroscopy to calculate a VE index. However, exact processes that are influencing the OIT in irradiated materials are unclear at this time. UHMWPE blended with VE in powder, consolidated and irradiated form were investigated. In addition, intralaboratory results give support that this technique may lend itself to standardization in quality control and verification.
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.33175