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Sepsis after major cancer surgery

Abstract Background Cancer patients undergoing procedures are at increased risk of sepsis. We sought to evaluate the incidence of postoperative sepsis following major cancer surgeries (MCS), and to describe patient and/or hospital characteristics associated with heightened risk. Methods Patients und...

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Bibliographic Details
Published in:The Journal of surgical research 2015-02, Vol.193 (2), p.788-794
Main Authors: Sammon, Jesse D., DO, Klett, Dane E., MD, Sood, Akshay, MD, Olugbade, Kola, MD, Schmid, Marianne, MD, Kim, Simon P., MD, Menon, Mani, MD, Trinh, Quoc-Dien, MD
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Language:English
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Summary:Abstract Background Cancer patients undergoing procedures are at increased risk of sepsis. We sought to evaluate the incidence of postoperative sepsis following major cancer surgeries (MCS), and to describe patient and/or hospital characteristics associated with heightened risk. Methods Patients undergoing 1 of 8 MCS (colectomy, cystectomy, esophagectomy, gastrectomy, hysterectomy, lung resection, pancreatectomy, and prostatectomy) within the Nationwide Inpatient Sample from 1999–2009 were identified ( N  = 2,502,710). Logistic regression models fitted with generalized estimating equations were used to estimate primary predictors (procedure, age, gender, race, insurance, Charlson Comorbidity Index, hospital volume, and hospital bed size) effect on sepsis and sepsis-associated mortality. Trends were evaluated with linear regression. Results The incidence of MCS-related sepsis increased 2.0% per year ( P  
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2014.07.046