Loading…

Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds

Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new me...

Full description

Saved in:

Bibliographic Details
Published in:	Chemical communications (Cambridge, England) England), 2014-07, Vol.50 (54), p.7139-7142
Main Authors:	Marculescu, Cristina, Kossen, Hanno, Morgan, Rachel E, Mayer, Patrick, Fletcher, Sally A, Tolner, Berend, Chester, Kerry A, Jones, Lyn H, Baker, James R
Format:	Article
Language:	English
Subjects:	Attenuation Bridging Chemical bonds Cysteine Cysteine - chemistry Disulfides Disulfides - chemistry GRB2 Adaptor Protein - chemistry Maleimides - chemical synthesis Maleimides - chemistry Proteins Somatostatin - chemistry Tuning
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c356t-298275c1eb34939fae55ae4377b4ada0b5cf8471d875ddd60bb05a721c8f4eeb3
cites	cdi_FETCH-LOGICAL-c356t-298275c1eb34939fae55ae4377b4ada0b5cf8471d875ddd60bb05a721c8f4eeb3
container_end_page	7142
container_issue	54
container_start_page	7139
container_title	Chemical communications (Cambridge, England)
container_volume	50
creator	Marculescu, Cristina Kossen, Hanno Morgan, Rachel E Mayer, Patrick Fletcher, Sally A Tolner, Berend Chester, Kerry A Jones, Lyn H Baker, James R
description	Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new methods for protein modification at disulfide bonds.
doi_str_mv	10.1039/c4cc02107j
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1642207492</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1534792732</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-298275c1eb34939fae55ae4377b4ada0b5cf8471d875ddd60bb05a721c8f4eeb3</originalsourceid><addsrcrecordid>eNqFkbtOwzAUhi0EoqWw8ADII0IEfI2TsYq4qhILSGyR40txlcRtnEiEpydpC2LjLOcM3_cP5wfgHKMbjGh6q5hSiGAkVgdgimnMIs6S98Px5mkkKOMTcBLCCg2DeXIMJoQlnMYxmYLNvOlL_9lXsjSuctoEaH0DVR9a42oDK6-ddUq2ztfXULvQlXagYNE4vXT1Espaw_bDQN3JEtquViMpS_e1VaC3fyVf63AKjqwsgznb7xl4u797zR6jxcvDUzZfRIryuI1ImhDBFTYFZSlNrTScS8OoEAWTWqKCK5swgXUiuNY6RkWBuBQEq8QyM1gzcLnLXTd-05nQ5pULypSlrI3vQo5jRggSLCX_o5wykRJBR_Rqh6rGh9AYm68bV8mmzzHKxzbyjGXZto3nAb7Y53ZFZfQv-vN--g3hW4db</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1534792732</pqid></control><display><type>article</type><title>Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds</title><source>Royal Society of Chemistry</source><creator>Marculescu, Cristina ; Kossen, Hanno ; Morgan, Rachel E ; Mayer, Patrick ; Fletcher, Sally A ; Tolner, Berend ; Chester, Kerry A ; Jones, Lyn H ; Baker, James R</creator><creatorcontrib>Marculescu, Cristina ; Kossen, Hanno ; Morgan, Rachel E ; Mayer, Patrick ; Fletcher, Sally A ; Tolner, Berend ; Chester, Kerry A ; Jones, Lyn H ; Baker, James R</creatorcontrib><description>Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new methods for protein modification at disulfide bonds.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c4cc02107j</identifier><identifier>PMID: 24853662</identifier><language>eng</language><publisher>England</publisher><subject>Attenuation ; Bridging ; Chemical bonds ; Cysteine ; Cysteine - chemistry ; Disulfides ; Disulfides - chemistry ; GRB2 Adaptor Protein - chemistry ; Maleimides - chemical synthesis ; Maleimides - chemistry ; Proteins ; Somatostatin - chemistry ; Tuning</subject><ispartof>Chemical communications (Cambridge, England), 2014-07, Vol.50 (54), p.7139-7142</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-298275c1eb34939fae55ae4377b4ada0b5cf8471d875ddd60bb05a721c8f4eeb3</citedby><cites>FETCH-LOGICAL-c356t-298275c1eb34939fae55ae4377b4ada0b5cf8471d875ddd60bb05a721c8f4eeb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24853662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marculescu, Cristina</creatorcontrib><creatorcontrib>Kossen, Hanno</creatorcontrib><creatorcontrib>Morgan, Rachel E</creatorcontrib><creatorcontrib>Mayer, Patrick</creatorcontrib><creatorcontrib>Fletcher, Sally A</creatorcontrib><creatorcontrib>Tolner, Berend</creatorcontrib><creatorcontrib>Chester, Kerry A</creatorcontrib><creatorcontrib>Jones, Lyn H</creatorcontrib><creatorcontrib>Baker, James R</creatorcontrib><title>Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new methods for protein modification at disulfide bonds.</description><subject>Attenuation</subject><subject>Bridging</subject><subject>Chemical bonds</subject><subject>Cysteine</subject><subject>Cysteine - chemistry</subject><subject>Disulfides</subject><subject>Disulfides - chemistry</subject><subject>GRB2 Adaptor Protein - chemistry</subject><subject>Maleimides - chemical synthesis</subject><subject>Maleimides - chemistry</subject><subject>Proteins</subject><subject>Somatostatin - chemistry</subject><subject>Tuning</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkbtOwzAUhi0EoqWw8ADII0IEfI2TsYq4qhILSGyR40txlcRtnEiEpydpC2LjLOcM3_cP5wfgHKMbjGh6q5hSiGAkVgdgimnMIs6S98Px5mkkKOMTcBLCCg2DeXIMJoQlnMYxmYLNvOlL_9lXsjSuctoEaH0DVR9a42oDK6-ddUq2ztfXULvQlXagYNE4vXT1Espaw_bDQN3JEtquViMpS_e1VaC3fyVf63AKjqwsgznb7xl4u797zR6jxcvDUzZfRIryuI1ImhDBFTYFZSlNrTScS8OoEAWTWqKCK5swgXUiuNY6RkWBuBQEq8QyM1gzcLnLXTd-05nQ5pULypSlrI3vQo5jRggSLCX_o5wykRJBR_Rqh6rGh9AYm68bV8mmzzHKxzbyjGXZto3nAb7Y53ZFZfQv-vN--g3hW4db</recordid><startdate>20140711</startdate><enddate>20140711</enddate><creator>Marculescu, Cristina</creator><creator>Kossen, Hanno</creator><creator>Morgan, Rachel E</creator><creator>Mayer, Patrick</creator><creator>Fletcher, Sally A</creator><creator>Tolner, Berend</creator><creator>Chester, Kerry A</creator><creator>Jones, Lyn H</creator><creator>Baker, James R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20140711</creationdate><title>Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds</title><author>Marculescu, Cristina ; Kossen, Hanno ; Morgan, Rachel E ; Mayer, Patrick ; Fletcher, Sally A ; Tolner, Berend ; Chester, Kerry A ; Jones, Lyn H ; Baker, James R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-298275c1eb34939fae55ae4377b4ada0b5cf8471d875ddd60bb05a721c8f4eeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Attenuation</topic><topic>Bridging</topic><topic>Chemical bonds</topic><topic>Cysteine</topic><topic>Cysteine - chemistry</topic><topic>Disulfides</topic><topic>Disulfides - chemistry</topic><topic>GRB2 Adaptor Protein - chemistry</topic><topic>Maleimides - chemical synthesis</topic><topic>Maleimides - chemistry</topic><topic>Proteins</topic><topic>Somatostatin - chemistry</topic><topic>Tuning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marculescu, Cristina</creatorcontrib><creatorcontrib>Kossen, Hanno</creatorcontrib><creatorcontrib>Morgan, Rachel E</creatorcontrib><creatorcontrib>Mayer, Patrick</creatorcontrib><creatorcontrib>Fletcher, Sally A</creatorcontrib><creatorcontrib>Tolner, Berend</creatorcontrib><creatorcontrib>Chester, Kerry A</creatorcontrib><creatorcontrib>Jones, Lyn H</creatorcontrib><creatorcontrib>Baker, James R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marculescu, Cristina</au><au>Kossen, Hanno</au><au>Morgan, Rachel E</au><au>Mayer, Patrick</au><au>Fletcher, Sally A</au><au>Tolner, Berend</au><au>Chester, Kerry A</au><au>Jones, Lyn H</au><au>Baker, James R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2014-07-11</date><risdate>2014</risdate><volume>50</volume><issue>54</issue><spage>7139</spage><epage>7142</epage><pages>7139-7142</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new methods for protein modification at disulfide bonds.</abstract><cop>England</cop><pmid>24853662</pmid><doi>10.1039/c4cc02107j</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 1359-7345
ispartof	Chemical communications (Cambridge, England), 2014-07, Vol.50 (54), p.7139-7142
issn	1359-7345 1364-548X
language	eng
recordid	cdi_proquest_miscellaneous_1642207492
source	Royal Society of Chemistry
subjects	Attenuation Bridging Chemical bonds Cysteine Cysteine - chemistry Disulfides Disulfides - chemistry GRB2 Adaptor Protein - chemistry Maleimides - chemical synthesis Maleimides - chemistry Proteins Somatostatin - chemistry Tuning
title	Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T14%3A48%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aryloxymaleimides%20for%20cysteine%20modification,%20disulfide%20bridging%20and%20the%20dual%20functionalization%20of%20disulfide%20bonds&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Marculescu,%20Cristina&rft.date=2014-07-11&rft.volume=50&rft.issue=54&rft.spage=7139&rft.epage=7142&rft.pages=7139-7142&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/c4cc02107j&rft_dat=%3Cproquest_cross%3E1534792732%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c356t-298275c1eb34939fae55ae4377b4ada0b5cf8471d875ddd60bb05a721c8f4eeb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1534792732&rft_id=info:pmid/24853662&rfr_iscdi=true