Modelling and optimisation of preparative chromatographic purification of europium

► Modelling of preparative separation of the REE using a strong acid. ► Cerium was a good substitute to the expensive elements in overloaded experiments. ► Optimisation of Eu separation regarding yield and productivity. ► It is possible to model and optimise the harsh system when separating small io...

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Bibliographic Details
Published in:Journal of Chromatography A 2012-01, Vol.1220 (13), p.21-25
Main Authors: Ojala, Frida, Max-Hansen, Mark, Kifle, Dejene, Borg, Niklas, Nilsson, Bernt
Format: Article
Language:English
Subjects:
biochemical compounds
Biomolecules
Calibration
Chromatography
Computer simulation
Europium
gadolinium
Ion-exchange chromatography
Kinetic dispersive model
Mathematical models
neodymium
Optimisation
Optimization
Rare earth elements
samarium
Separation
sorption isotherms
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Summary:► Modelling of preparative separation of the REE using a strong acid. ► Cerium was a good substitute to the expensive elements in overloaded experiments. ► Optimisation of Eu separation regarding yield and productivity. ► It is possible to model and optimise the harsh system when separating small ions. A model commonly used to describe the separation of biomolecules was used to simulate the harsh environment when eluting neodymium, samarium, europium and gadolinium with a hot acid. After calibration, the model was used to optimise the preparative separation of europium, as this is the most valuable of the four elements. A kinetic dispersive model with a Langmuir mobile phase modulator isotherm was used to describe the process. The equilibration constant, the stoichiometric coefficient and the column capacity for the components were calibrated. The model fitted the experimental observations well. Optimisation was achieved using a differential evolution method. As the two objective functions used in optimising the process, productivity and yield, are competing objectives, the result was not a single set point but a Pareto front.
ISSN:0021-9673
DOI:10.1016/j.chroma.2011.11.028