Mucormycosis in haematological patients: case report and results of prospective study in Saint Petersburg, Russia

Summary We prospectively observed 36 haematological patients with mucormycosis from nine hospitals of St. Petersburg during 2004–2013. The most frequent underlying diseases were acute leukaemia (64%), and main risk factors were prolonged neutropenia (92%) and lymphocytopenia (86%). In 50% of the pat...

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Bibliographic Details
Published in:Mycoses 2014-12, Vol.57 (s3), p.91-96
Main Authors: Klimko, Nikolay N., Khostelidi, Sofya N., Volkova, Alisya G., Popova, Marina O., Bogomolova, Tatyana S., Zuborovskaya, Ludmila S., Kolbin, Aleksey S., Medvedeva, Nadezhda V., Zuzgin, Ilya S., Simkin, Sergey M., Vasilyeva, Nataliya V., Afanasiev, Boris V.
Format: Article
Language:English
Subjects:
acute leukaemia
Adolescent
Adult
Aged
Amphotericin B - therapeutic use
Antifungal Agents - therapeutic use
Aspergillus
Child
Drug Combinations
Echinocandins - therapeutic use
Female
haematological malignancy
Humans
Lichtheimia corymbifera
Lymphopenia - drug therapy
Lymphopenia - microbiology
Male
Middle Aged
Mucormycosis
Mucormycosis - drug therapy
Mucormycosis - epidemiology
Neutropenia - drug therapy
Neutropenia - microbiology
Prospective Studies
pulmonary mucormycosis
Rhizopus
Rhizopus - classification
Rhizopus - pathogenicity
Risk Factors
Russia - epidemiology
skin and soft tissue
Young Adult
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Summary:Summary We prospectively observed 36 haematological patients with mucormycosis from nine hospitals of St. Petersburg during 2004–2013. The most frequent underlying diseases were acute leukaemia (64%), and main risk factors were prolonged neutropenia (92%) and lymphocytopenia (86%). In 50% of the patients, mucormycosis was diagnosed 1–65 days after invasive aspergillosis. Main clinical form of mucormycosis was pulmonary (64%), while two or more organ involvement was noted in 50% of the cases. The most frequent aetiological agents of mucormycosis were Rhizopus spp. (48%). Twelve‐week survival rate was 50%. Combination therapy (echinocandins + amphotericin B forms) and recovery from the underlying disease significantly improved the survival rate.
ISSN:0933-7407
1439-0507
DOI:10.1111/myc.12247