Field dissipation and health hazard assessment of Fenhexamid on Egyptian grapes

• Published in: Toxicological and environmental chemistry 2014-05, Vol.96 (5), p.722-729
• Main Authors: Malhat, Farag M., El Sharkawi, Haytham M., Loutfy, Naglaa M., Ahmed, Mohamed Tawfic
• Format: Article
• Language: English
• Subjects: Assessments; Berries; Chromatography; Consumers; Dissipation; fenhexamid; Fungicides; grape; Grapes; Hazard assessment; Hazards; health hazard; Health hazards; Pesticides; QuEChERS; Residues; Vitaceae
• ISSN: 0277-2248; 1029-0486
• DOI: 10.1080/02772248.2014.980130

Dissipation behavior and hazard assessment of the fungicide fenhexamid applied to grapes were investigated under climatic conditions in Egypt. Fenhexamid residues were extracted from grape samples with ethyl acetate. The extract was cleaned up by QuEChERS (quick, easy, cheap, effective, rugged, and safe) method, and determined by gas chromatographic method (GC-μECD). The average recoveries ranged between 94.2% and 99.4% with associated relative standard deviation not exceeding 12%. The estimated limit of quantification for fenhexamid was 0.1 mg/kg. The field results showed that fenhexamid dissipated rapidly from grapes and had a half-life of approximately 4.21 days. Hazard assessment was evaluated by using the hazard quotient (HQ). Data showed that the HQ value was significantly less than HQ = 1. Results indicate that hazard of fenhexamid use in grape even at 1.5-fold higher than recommended dosage was negligible to humans. This study could provide guidance for safe and reasonable use of fenhexamid in grapes and prevent health problems to consumers. However, further hazard assessment studies are needed to ascertain the hazard of fenhexamid residues on grape to vulnerable groups, including children, pregnant women, and elderly consumers.