Blunted IL-6 and IL-10 response to maximal aerobic exercise in patients with traumatic brain injury

Introduction In healthy individuals, strenuous exercise typically results in a transient increase in the inflammatory cytokine, interleukin-6 (IL-6). This increase in IL-6 is reported to have pleiotropic effects including increased glucose uptake, increased fat oxidation, and anti-inflammatory actio...

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Bibliographic Details
Published in:European journal of applied physiology 2015-01, Vol.115 (1), p.111-118
Main Authors: Timmerman, Kyle L., Amonette, William E., Markofski, Melissa M., Ansinelli, Hayden A., Gleason, Elizabeth A., Rasmussen, Blake B., Mossberg, Kurt A.
Format: Article
Language:English
Subjects:
Adult
Aerobics
Biomedical and Life Sciences
Biomedicine
Brain Injuries - metabolism
Case-Control Studies
Cytokines
Exercise
Female
Fitness training programs
Glucose
Hormones
Human Physiology
Humans
Hydrocortisone - blood
Interleukin-10 - blood
Interleukin-6 - blood
Male
Musculoskeletal system
Nervous system
Occupational Medicine/Industrial Medicine
Original Article
Oxidation
Physical fitness
Sports Medicine
Traumatic brain injury
Tumor Necrosis Factor-alpha - blood
Tumor necrosis factor-TNF
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Summary:Introduction In healthy individuals, strenuous exercise typically results in a transient increase in the inflammatory cytokine, interleukin-6 (IL-6). This increase in IL-6 is reported to have pleiotropic effects including increased glucose uptake, increased fat oxidation, and anti-inflammatory actions. Purpose The purpose of this study was to determine if patients with a traumatic brain injury (TBI) have a differential cytokine response to exercise compared to healthy control subjects (CON). Methods Eight patients with a TBI and eight age- and sex-matched controls completed an exercise test to volitional exhaustion. Metabolic data were collected continuously, and blood was collected at baseline, immediately post-exercise, and every 10 min for an hour post-exercise. Serum was analyzed for IL-6, tumor necrosis factor-alpha, interleukin-10 (IL-10), and cortisol. Results Peak oxygen consumption (CON 33 ± 2 ml kg −1  min −1 ; TBI 29 ± 2 ml kg −1  min −1 ) and respiratory exchange ratio during exercise were equivalent between groups. There were no baseline differences between groups for cytokine or cortisol concentrations. Exercise did not increase IL-6 in TBI, whereas IL-6 was elevated from baseline in CON at 0, 40, and 50 min post-exercise ( p  
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-014-2997-4