CCR5/Δccr5 Heterozygosity: A Selective Pressure for the Syncytium-Inducing Human Immunodeficiency Virus Type 1 Phenotype

Mechanisms underlying the delay in dominance of syncytium-inducing (SI) phenotype HIV-1 (human immunodeficiency virus type 1) in vivo are unknown. Both random mutational events and selective pressures operative only late in the disease process have been suggested to underlie the shift from CCR5 to a...

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Bibliographic Details
Published in:The Journal of infectious diseases 1998-06, Vol.177 (6), p.1549-1553
Main Authors: D'Aquila, Richard T., Sutton, Lorraine, Anu, Savara, Michael D., Hughes, Johnson, Victoria A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Human viral diseases
Infectious diseases
Medical sciences
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Mechanisms underlying the delay in dominance of syncytium-inducing (SI) phenotype HIV-1 (human immunodeficiency virus type 1) in vivo are unknown. Both random mutational events and selective pressures operative only late in the disease process have been suggested to underlie the shift from CCR5 to alternative coreceptor usage. Among the moderately advanced patients who entered AIDS Clinical Trials Group protocol 241, SI viral phenotype was more common among CCR5/Δccr5 heterozygotes (7/7, 100%) than among CCR5/CCR5 homozygotes (29/88, 33%; P
ISSN:0022-1899
1537-6613
DOI:10.1086/515307