No Association between Calcium Channel Blocker Use and Confirmed Bleeding Peptic Ulcer Disease

Calcium channel antagonists are commonly used drugs that have recently been reported to be associated with an increased incidence of gastrointestinal hemorrhage. We performed a retrospective cohort study among 105, 824 enrollees of the Tennessee Medicaid program 65 years of age or older between 1984...

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Bibliographic Details
Published in:American journal of epidemiology 1998-08, Vol.148 (4), p.350-354
Main Authors: Smalley, Walter E., Ray, Wayne A., Daugherty, James R., Griffin, Marie R.
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - adverse effects
Aged
Aged, 80 and over
antihypertensive agents
Biological and medical sciences
calcium channel blockers
Calcium Channel Blockers - adverse effects
Cohort Studies
Drug toxicity and drugs side effects treatment
Female
gastrointestinal hemorrhage
Hospitalization
Humans
Male
Medicaid
Medical sciences
Peptic Ulcer - chemically induced
Peptic Ulcer - epidemiology
Pharmacology. Drug treatments
Tennessee - epidemiology
Toxicity: digestive system
United States
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Summary:Calcium channel antagonists are commonly used drugs that have recently been reported to be associated with an increased incidence of gastrointestinal hemorrhage. We performed a retrospective cohort study among 105, 824 enrollees of the Tennessee Medicaid program 65 years of age or older between 1984 and 1986. Exposure to calcium channel blockers and other medications was determined from pharmacy files. Hospitalization for bleeding peptic ulcers was identified by hospital claims and verified by a review of the medical record. Univariate estimates of relative risk for current users of calcium channel blockers and beta-blocker users were 1.8 (95% confidence interval (Cl) 1.2–2.7) and 1.1 (95% Cl 0.7–1.6) (reference group was nonuse of either). After adjustment for potential confounders, the relative risks for bleeding peptic ulcer among current users of calcium channel blockers and beta btockers were 1.1 (95% Cl 0.7–1.7) and 1.0 (95% Cl 0.7–1.6), respectively, when compared with those who used neither drug. In this population, after controlling for important confounders, there was no increased risk for hospitalization with bleeding peptic ulcer among users of calcium channel blockers. Am J Epidemiol 1998; 148:350–4.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a009652