Pulmonary Responses to Oil Fly Ash Particles in the Rat Differ by Virtue of Their Specific Soluble Metals

Occupational exposure to residual oil fly ash (ROFA) particulate has been associated with adverse respiratory health effects in humans. We hypothesized that ROFA collected at different sites within an oil burning power plant, by virtue of its differing metal and sulfate composition, will induce diff...

Full description

Saved in:
Bibliographic Details
Published in:Toxicological sciences 1998-06, Vol.43 (2), p.204-212
Main Authors: Kodavanti, Urmila P., Hauser, Russ, Christiani, David C., Meng, Zhi H., McGee, John, Ledbetter, Allen, Richards, Judy, Costa, Daniel L.
Format: Article
Language:English
Subjects:
Air
Animals
Biological and medical sciences
Bronchoalveolar Lavage Fluid
Capillary Permeability - drug effects
Carbon - toxicity
Coal Ash
Environmental pollutants toxicology
Luminescent Measurements
Luminol
Lung - blood supply
Lung - drug effects
Macrophages, Alveolar - drug effects
Macrophages, Alveolar - metabolism
Male
Medical sciences
Oxidation-Reduction
Particulate Matter
Petroleum
Rats
Rats, Sprague-Dawley
Toxicology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Occupational exposure to residual oil fly ash (ROFA) particulate has been associated with adverse respiratory health effects in humans. We hypothesized that ROFA collected at different sites within an oil burning power plant, by virtue of its differing metal and sulfate composition, will induce differential lung injury. Ten ROFA samples collected at various sites within a power plant were analyzed for water- and 1.0 M HCl-leachable arsenic (As), beryllium (Be), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), lead (Pb), vanadium (V), zinc (Zn), and sulfur by inductively coupled plasma–atomic emission spectroscopy. All ROFA samples contained variable amounts of leachable (water-extractable) and 1.0 M HCl-extractable Fe, V, and/or Ni. All other metals, except Zn (ROFA No. 1 contained 3.43 and No. 3, 6.35 μg/mg Zn), were present in negligible quantities (
ISSN:1096-6080
1096-0929
DOI:10.1006/toxs.1998.2460