Studies on the antioxidant activity of some thiazolidinedione, imidazolidinedione and rhodanine derivatives having a flavone core

ABSTRACT A series of flavonyl‐2,4‐thiazolidinedione, imidazolidinedione and rhodanine derivatives were tested for their antioxidant activity as scavengers of oxygen free radicals. Free radical scavenging activities, including superoxide anion radical O2•¯, hydroxyl radical (HO•) and 2,2′‐diphenyl‐1‐...

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Published in:Luminescence (Chichester, England) England), 2014-12, Vol.29 (8), p.1107-1112
Main Authors: Berczyński, Paweł, Kładna, Aleksandra, Piechowska, Teresa, Kruk, Irena, Bozdağ-Dündar, Oya, Aboul-Enein, Hassan Y., Ceylan-Unlusoy, Meltem, Ertan, Rahmiye
Format: Article
Language:English
Subjects:
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Biphenyl Compounds - chemistry
Chemiluminescence
Derivatives
Electron Spin Resonance Spectroscopy
EPR study
Ethers
flavone derivatives
Flavones - chemistry
Flavones - pharmacology
Free Radical Scavengers - chemistry
Free Radical Scavengers - pharmacology
Free radicals
Hydroxyl Radical
Hydroxyl radicals
Luminescence
Picrates - chemistry
radical scavenging activity
Radicals
Scavenging
Superoxides - chemistry
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Summary:ABSTRACT A series of flavonyl‐2,4‐thiazolidinedione, imidazolidinedione and rhodanine derivatives were tested for their antioxidant activity as scavengers of oxygen free radicals. Free radical scavenging activities, including superoxide anion radical O2•¯, hydroxyl radical (HO•) and 2,2′‐diphenyl‐1‐picrylhydrazyl free radical have been evaluated using chemiluminescence, electron paramagnetic resonance and spin trapping with 5,5‐dimethyl‐1‐pyrroline‐1‐oxide as a spin trap. Potassium superoxide in dimethylsulfoxide and 18‐crown‐6 ether were used for the production of O2•¯. Hydroxyl radical was generated using the Fenton reaction. Ten of the eleven examined compounds exhibited decrease in chemiluminescence, but there were large differences in the decrease, ranging from 16% to 89%; also, two of these compounds increased light emission by about 200%. On the contrary, all compounds tested exhibited 30–68% scavenging HO• and 25–96% scavenging the DPPH• radical respectively. Possible mechanisms are proposed to explain the results. Copyright © 2014 John Wiley & Sons, Ltd.
ISSN:1522-7235
1522-7243
DOI:10.1002/bio.2667