Asthma and insulin resistance in obese children and adolescents

Background Obese children and adolescents have an increased risk for asthma. A few studies have evaluated the association of insulin resistance and asthma in obese pediatric populations. We examined whether there was a relationship between high degrees of insulin resistance and the presence of asthm...

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Published in:Pediatric allergy and immunology 2014-11, Vol.25 (7), p.699-705
Main Authors: Sánchez Jiménez, José, Herrero Espinet, F. Javier, Mengibar Garrido, José M., Roca Antonio, Josep, Peños Mayor, Sara, Peñas Boira, María del Mar, Roca Comas, Amadeu, Ballester Martínez, Anna
Format: Article
Language:English
Subjects:
Adolescent
adolescents
Air Pollutants - immunology
Allergens - immunology
Asthma
Asthma - epidemiology
Body Mass Index
Child
Child, Preschool
children
Female
Humans
Insulin
Insulin Resistance
Male
Obesity
Obesity - epidemiology
Prospective Studies
Skin Tests
Spirometry
Teenagers
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Summary:Background Obese children and adolescents have an increased risk for asthma. A few studies have evaluated the association of insulin resistance and asthma in obese pediatric populations. We examined whether there was a relationship between high degrees of insulin resistance and the presence of asthma in obese children and adolescents. Methods A total of 153 patients aged 4–15 years with at or above the 95th percentile BMI for age were prospectively recruited. Assessments included diagnosis of asthma, skin prick test reactivity to common environmental aeroallergens, and HOMA estimated insulin resistance, with the median (2.22) used as a cutoff value to categorize insulin resistance. Results There were 56 (36.6%) asthmatic and 97 (63.4%) non‐asthmatic patients. HOMA values were significantly associated with positive skin tests (p = 0.008) and allergic asthma diagnosis (p = 0.016). Baseline insulin value was significantly associated with the risk of presenting asthma with positive skin testing (odds ratio 1.084, p = 0.037). Differences in age, BMI, and waist circumference were found between the groups of HOMA‐IR
ISSN:0905-6157
1399-3038
DOI:10.1111/pai.12294