The impact of the peritoneal glucose load index on hydration status and inflammation in peritoneal dialysis patients

• Published in: Journal of international medical research 2015-02, Vol.43 (1), p.42-53
• Main Authors: Hassan, Kamal, Hassan, Fadi, Edgem, Rabia, Moshe, Smadar, Hassan, Shadi
• Format: Article
• Language: English
• Subjects: C-Reactive Protein - metabolism; Demography; Diabetes Mellitus - blood; Dialysis Solutions - pharmacology; Female; Glucose - metabolism; Glycated Hemoglobin A - metabolism; Humans; Inflammation - blood; Inflammation - pathology; Interleukin-6 - blood; Male; Middle Aged; Peritoneal Dialysis; Reproducibility of Results; ROC Curve
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/0300060514550013

Objective To evaluate the impact of the peritoneal glucose load (PGL) on hydration status and inflammation in peritoneal dialysis (PD) patients. Methods This cross-sectional study evaluated stable PD patients using a novel PGL index (PGLI), which was calculated as the net glucose content (g) in the PD solutions administered in the daily PD prescription divided by the dry body weight (kg) assessed by whole-body bioimpedance spectroscopy. The relationship between PGLI and glycosylated haemoglobin (HbA1c), fluid overload (FO), and inflammatory markers was investigated. Results A total of 43 stable PD patients participated in the study. Significant positive correlations were found between PGLI and HbA1c, FO, plasma high sensitivity C-reactive protein (hsCRP), and plasma interleukin-6 (IL-6) levels. HbA1c, FO, plasma hsCRP and plasma IL-6 levels were significantly higher in patients with PGLI >3 g/kg/day compared with those with PGLI ≤3 g/kg/day. Conclusions PGLI values >3 g/kg/day may be associated with poor glycaemic control, over hydration and augmented inflammation. PGLI might be a useful tool for the quantitative assessment of the PGL and could be applied when managing PD patients.