Carriage niches and molecular epidemiology of Staphylococcus lugdunensis and methicillin-resistant S. lugdunensis among patients undergoing long-term renal replacement therapy

Abstract We collected nasal, axilla, and groin swabs from 252 adult patients from 2 nephrology centers in Hong Kong. Staphylococcus lugdunensis carriage was detected in 51.6% patients (groin, 39.3%; axilla, 19.8%; nose, 17.9%). The carriage rates of methicillin-sensitive S. lugdunensis and methicill...

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Published in:Diagnostic microbiology and infectious disease 2015-02, Vol.81 (2), p.141-144
Main Authors: Ho, Pak-Leung, Leung, Sammy Man-Him, Chow, Kin-Hung, Tse, Cindy Wing-Sze, Cheng, Vincent Chi-Chung, Tse, Herman, Mak, Siu-Ka, Lo, Wai-Kei
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antimicrobial resistance
Carrier State - epidemiology
Carrier State - microbiology
Cross-Sectional Studies
Electrophoresis, Gel, Pulsed-Field
Female
Genotype
Hong Kong - epidemiology
Humans
Infectious Disease
Internal Medicine
Male
Methicillin Resistance
Middle Aged
Molecular Epidemiology
Molecular Typing
Renal Replacement Therapy
Risk Factors
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcus lugdunensis
Staphylococcus lugdunensis - classification
Staphylococcus lugdunensis - drug effects
Staphylococcus lugdunensis - genetics
Staphylococcus lugdunensis - isolation & purification
Young Adult
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Summary:Abstract We collected nasal, axilla, and groin swabs from 252 adult patients from 2 nephrology centers in Hong Kong. Staphylococcus lugdunensis carriage was detected in 51.6% patients (groin, 39.3%; axilla, 19.8%; nose, 17.9%). The carriage rates of methicillin-sensitive S. lugdunensis and methicillin-resistant S. lugdunensis (MRSL) were 46.0% and 8.3%, respectively. Independent risk factors for S. lugdunensis carriage included male sex (odds ratio [OR], 4.4), hemodialysis (OR, 2.2), and aged 18–50 years (OR, 2.4). The isolates belonged to 10 pulsotype clusters (n = 129) and 8 singletons (n = 8). All MRSL and most gentamicin- and tetracycline-resistant strains were found in a predominating sequence type 3 clone, designated HKU1, which accounted for 51.8% of all colonizing S. lugdunensis strains. The 21 MRSL isolates had SCC mec type V (n = 18), type IV (n = 2), and type I (n = 1). The finding highlights the potential for dissemination of multidrug resistance through successful S. lugdunensis clones.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2014.10.004