A prospective study on pulse wave velocity (PWV) and response to anti-hypertensive treatments: PWV determines BP control

• Published in: International journal of cardiology 2015-01, Vol.178, p.226-231
• Main Authors: Zheng, Meili, Huo, Yong, Wang, Xiaobin, Xu, Xin, Qin, Xianhui, Tang, Genfu, Xing, Houxun, Fan, Fangfang, Li, Jianping, Zhang, Yan, Wang, Binyan, Xu, Xiping, Yang, Xinchun, Chen, Yundai, Qian, Geng
• Format: Article
• Language: English
• Subjects: Aged; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Blood Pressure - drug effects; Blood Pressure - physiology; Blood Pressure Determination - methods; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypertension - diagnosis; Hypertension - drug therapy; Hypertension - physiopathology; Male; Middle Aged; Prospective Studies; Pulse Wave Analysis - methods; Treatment Outcome
• ISSN: 1874-1754
• DOI: 10.1016/j.ijcard.2014.10.049

Recent data indicate that hypertension is not well controlled in many populations throughout the world. The factors that influence individual response to anti-hypertensive treatment need to be clarified. Pulse wave velocity (PWV), as a marker of arterial stiffness, has been demonstrated to have important relationships with BP progression; however, little information is available on the role of PWV in blood pressure (BP) control. We aimed to assess BP control during the run-in treatment period in the China Stroke Primary Prevention Trial (CSPPT). These analyses included a total of 3056 treated hypertensive subjects (age: 59.6±7.5years, male/female 1339/1717) with PWV measured at baseline. The average BP at enrollment was 166/95mmHg, and declined to 141/85mmHg after short-term antihypertensive treatment (a median follow-up of 20days). There was an inverse relationship between PWV level and BP reduction during the treatment, most notably for systolic BP (with estimated coefficients of -9.01 (P