Iron administration prevents BDNF decrease and depressive-like behavior following chronic stress

Abstract Pro-inflammatory cytokines play important roles in responses to stresses and affect iron metabolism. Iron is essential for survival of hippocampus neurons and plays a role in depression. Noting the close causal effect relation between stress and depression, in this experimental study we inv...

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Published in:Brain research 2015-01, Vol.1596, p.79-87
Main Authors: Mehrpouya, Sara, Nahavandi, Arezo, Khojasteh, Fatemeh, Soleimani, Mansoureh, Ahmadi, Mohammad, Barati, Mahmood
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Chronic Disease
Depression - drug therapy
Depression - etiology
Disease Models, Animal
Dose-Response Relationship, Drug
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Interleukin-6 - metabolism
Iron
Iron - administration & dosage
Iron - metabolism
Male
Neurology
Rats
Rats, Wistar
Stress, Psychological - complications
Stress-induced depression
Swimming - psychology
Time Factors
Trace Elements - administration & dosage
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Summary:Abstract Pro-inflammatory cytokines play important roles in responses to stresses and affect iron metabolism. Iron is essential for survival of hippocampus neurons and plays a role in depression. Noting the close causal effect relation between stress and depression, in this experimental study we investigated the influence of iron on stress-induced depression. Rats were exposed to chronic mild stress and were treated with three different iron doses (9, 12, and 20 mg/kg) three times a week for four weeks with an iron chelator in the first and third week. Serum interleukin-6 (enzyme-linked immune sorbent assay), hippocampus iron content (atomic absorption spectrometry), brain-derived neurotrophic factor (BDNF) gene expression (real-time polymerase chain reaction), CA1 pyramidal cell count (Nissl method) and a behavioral test (forced swimming test) were evaluated. In both the stressed and stressed plus iron groups, hippocampus cell counts were lower than in the control group (non-stressed). The use of deferiprone in the stressed groups markedly prevented neuronal loss. In stressed rats, the iron content of the hippocampus was higher than in the control group (P
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2014.10.057