Thermo-physical examination: Synthesized 2-furano-4(3H)-quinazolinone and open quinazolinone (diamide) anticancer analogs with sodium dodecyl sulfate

•In this study, interaction of two synthesized analogs and SDS has been examined.•Thermo-acoustic parameters were calculated from density and ultrasonic sound velocity data.•Existence of hydrophobic and electrostatic forces was observed.•Spectroscopic study provided the locus of molecules within mic...

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Bibliographic Details
Published in:Thermochimica acta 2013-12, Vol.573, p.65-72
Main Authors: Bhardwaj, Varun, Sharma, Poonam, Noolvi, Malleshappa N., Patel, Harun M., Chauhan, S., Chauhan, M.S., Sharma, Kundan
Format: Article
Language:English
Subjects:
compressibility
Fourier transform infrared spectroscopy
nuclear magnetic resonance spectroscopy
physicochemical properties
Quinazolinone
sodium dodecyl sulfate
Spectroscopic analysis
temperature
Thermodynamic
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Summary:•In this study, interaction of two synthesized analogs and SDS has been examined.•Thermo-acoustic parameters were calculated from density and ultrasonic sound velocity data.•Existence of hydrophobic and electrostatic forces was observed.•Spectroscopic study provided the locus of molecules within micellar structure. In this study, the solution and self aggregation properties of sodium dodecyl sulfate (SDS) in presence of synthesized small molecules i.e. 3-(2-chloro benzylideneamine))-2-(furan-2-yl) quinazoline-4(3H) one (Q1) and N-(2-(p-tolyl carbamoyl) phenyl) furan-2-carboxamide (Q2) has been determined. The two compounds were earlier screened for anticancer activity from NCI, USA. In order to investigate the physico-chemical properties, simple and controlled methods were employed to obtain critical micellar concentration (CMC) values and thermo-acoustic parameters via conductance, compressibility coefficient (β), apparent molar volume (ϕv) and apparent molar adiabatic compressibility (ϕk) of SDS in the presence of Q1/Q2 at different temperatures (25, 30, and 35°C). In addition, the effect of the addition of Q1/Q2 in SDS solution and to gain information regarding interaction between the molecules, FTIR and 1H NMR spectroscopic analysis was also carried out. The presence of different substitutions on the molecules affecting SDS behavior has also been discussed.
ISSN:0040-6031
1872-762X
DOI:10.1016/j.tca.2013.09.013