Theory of mind and decision-making processes are impaired in Parkinson's disease

•PD patients were impaired on the affective ToM and decision making.•The ability of affective ToM was affected by the severity of the disease.•The affective ToM and IGT may share similar neural mechanisms.•Memory impairment in PD could affect GDT selection strategy. Prefrontal cortex plays a vital r...

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Bibliographic Details
Published in:Behavioural brain research 2015-02, Vol.279, p.226-233
Main Authors: Xi, Chunhua, Zhu, Youling, Mu, Yanfang, Chen, Bing, Dong, Bin, Cheng, Huaidong, Hu, Panpan, Zhu, Chunyan, Wang, Kai
Format: Article
Language:English
Subjects:
Affect
Cognition
Decision Making
Female
Humans
Male
Middle Aged
Parkinson Disease - psychology
Parkinson's disease
Recognition (Psychology)
Risk
Theory of Mind
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Summary:•PD patients were impaired on the affective ToM and decision making.•The ability of affective ToM was affected by the severity of the disease.•The affective ToM and IGT may share similar neural mechanisms.•Memory impairment in PD could affect GDT selection strategy. Prefrontal cortex plays a vital role in the theory of mind (ToM) and decision making, as shown in functional brain imaging and lesion studies. Considering the primary neuropathology of Parkinson's disease (PD) involving the frontal lobe system, patients with PD are expected to exhibit deficits in ToM and social decision making. The aim of this study was to investigate affective ToM and decision making in patients with PD and healthy controls (HC) in a task assessing affective ToM (Reading the Mind in the Eyes, RME) and two decision-making tasks (Iowa Gambling Task, IGT; Game of Dice Task, GDT). Consistent with previous findings, patients with PD were impaired in the affective ToM task, and when making decisions under ambiguity and in risk situations. The score of emotion recognition in the RME task was negatively correlated with the severity of the disease and positively correlated with the total number of advantageous cards chosen in the IGT. However, the final capital in the GDT was correlated with memory impairment. The present study implies that affective ToM and decision making under ambiguity may share similar neural mechanisms, while decision making under ambiguity and decision making under risk may involve processing within different neural networks.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2014.11.035