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Prediction of biochemical recurrence after robot-assisted radical prostatectomy: Analysis of 784 Japanese patients
Objectives To examine biochemical recurrence after robot‐assisted radical prostatectomy in Japanese patients, and to develop a risk stratification model for biochemical recurrence. Methods The study cohort consisted of 784 patients with localized prostate cancer who underwent robot‐assisted radical...
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Published in: | International journal of urology 2015-02, Vol.22 (2), p.188-193 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Objectives
To examine biochemical recurrence after robot‐assisted radical prostatectomy in Japanese patients, and to develop a risk stratification model for biochemical recurrence.
Methods
The study cohort consisted of 784 patients with localized prostate cancer who underwent robot‐assisted radical prostatectomy without neoadjuvant or adjuvant endocrine therapy. The relationships of biochemical recurrence with perioperative findings were evaluated. The prognostic factors for biochemical recurrence‐free survival were evaluated using Cox proportional hazard model analyses.
Results
During the follow‐up period, 80 patients showed biochemical recurrence. The biochemical recurrence‐free survival rates at 1, 3, and 5 years were 92.2%, 85.2% and 80.1%, respectively. In univariate analysis, the prostate‐specific antigen level, prostate‐specific antigen density, biopsy Gleason score, percent positive core, pathological T stage, pathological Gleason score, lymphovascular invasion, perineural invasion and positive surgical margin were significantly associated with biochemical recurrence. In multivariate analysis, prostate‐specific antigen density ≥0.4 (P = 0.0011), pathological T stage ≥3a (P = 0.002), pathological Gleason score ≥8 (P = 0.007) and positive surgical margin (P |
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ISSN: | 0919-8172 1442-2042 |
DOI: | 10.1111/iju.12624 |