The modest alcohol consumption reduces the incidence of fatty liver in men: a population-based large-scale cohort study

Background and Aim Recent cross‐sectional studies have been reported the possibility that light to moderate alcohol consumption might be negatively associated with fatty liver. However, there has been no large‐scale longitudinal study addressing an impact of alcohol consumption on a development of f...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2015-03, Vol.30 (3), p.546-552
Main Authors: Hashimoto, Yoshitaka, Hamaguchi, Masahide, Kojima, Takao, Ohshima, Yasuhiro, Ohbora, Akihiro, Kato, Takahiro, Nakamura, Naoto, Fukui, Michiaki
Format: Article
Language:English
Subjects:
Adult
Alcohol Drinking
Asian Continental Ancestry Group
Body Mass Index
Cohort Studies
epidemiology
fatty liver
Fatty Liver - diagnostic imaging
Fatty Liver - epidemiology
Fatty Liver - prevention & control
Humans
Incidence
Life Style
Male
Middle Aged
NAFLD
obesity
Proportional Hazards Models
Sex Characteristics
Surveys and Questionnaires
Ultrasonography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Aim Recent cross‐sectional studies have been reported the possibility that light to moderate alcohol consumption might be negatively associated with fatty liver. However, there has been no large‐scale longitudinal study addressing an impact of alcohol consumption on a development of fatty liver diagnosed by ultrasonography. Thus, we investigated the impact of alcohol consumption on a natural history of fatty liver. Methods We analyzed 5437 apparently healthy Japanese who received the health checkup programs repeatedly over 10 years. In this study, we used a standardized questionnaire for addressing the medical history and lifestyle and used a standardized ultrasonographic diagnosis for fatty liver. The total amount of alcohol consumed per week was calculated and classified into four grades; none or minimal, light, moderate, or heavy alcohol consumption ( 280 g/week, respectively). The hazard risks of alcohol consumption for the development of fatty liver were calculated by Cox hazard model after adjusting age, BMI, and parameters for lifestyle. Results During 10 years of follow‐up, fatty liver was continuously diagnosed just in 10% of men and 20% of women with fatty liver at the baseline. In men, the adjusted hazard risks of light and moderate alcohol consumption for the development of fatty liver were 0.72 (95% confidence interval 0.60–0.86, P 
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.12786