Mg and Mg alloys: How comparable are in vitro and in vivo corrosion rates? A review

[Display omitted] Due to their biodegradability, magnesium and magnesium-based alloys could represent the third generation of biomaterials. However, their mechanical properties and time of degradation have to match the needs of applications. Several approaches, such as choice of alloying elements or...

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Bibliographic Details
Published in:Acta biomaterialia 2015-02, Vol.13, p.16-31
Main Authors: Sanchez, Adela Helvia Martinez, Luthringer, Bérengère J.C., Feyerabend, Frank, Willumeit, Regine
Format: Article
Language:English
Subjects:
Absorbable Implants
Alloys - pharmacokinetics
Alloys - pharmacology
Animals
Biodegradable metallic implants
Biomaterials
Corrosion
Humans
In vitro and in vivo corrosion
Magnesium - pharmacokinetics
Magnesium - pharmacology
Magnesium alloys
Models, Biological
Orthopaedics
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Summary:[Display omitted] Due to their biodegradability, magnesium and magnesium-based alloys could represent the third generation of biomaterials. However, their mechanical properties and time of degradation have to match the needs of applications. Several approaches, such as choice of alloying elements or tailored microstructure, are employed to tailor corrosion behaviour. Due to the high electrochemical activity of Mg, numerous environmental factors (e.g. temperature and surrounding ion composition) influence its corrosion behaviour, making it unpredictable. Nevertheless, the need of reliable in vitro model(s) to predict in vivo implant degradation is increasing. In an attempt to find a correlation between in vitro and vivo corrosion rates, this review presents a systematic literature survey, as well as an attempt to correlate the different results.
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2014.11.048