Organocatalytic Enantioselective Sulfur-Michael Addition of Thioacetic Acid to Arylmethylidenemalonates

An organocatalytic enantioselective sulfur‐Michael addition of thioacetic acid to arylmethylidenemalonates was developed with high yields and up to 97% enantiomeric excess. Both enantiomers of the products were accessible with two different organocatalysts. The current method provides the first, pra...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2015-01, Vol.357 (1), p.159-167
Main Authors: Wang, Renchao, Liu, Jing, Xu, Jiaxi
Format: Article
Language:English
Subjects:
Accessibility
alkylidenemalonates
Catalysis
Derivatives
Enantiomers
Enrichment
Michael addition
Michael reaction
organocatalysis
Synthesis
thioacetic acid
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Summary:An organocatalytic enantioselective sulfur‐Michael addition of thioacetic acid to arylmethylidenemalonates was developed with high yields and up to 97% enantiomeric excess. Both enantiomers of the products were accessible with two different organocatalysts. The current method provides the first, practical, and convenient preparation of enantiomerically enriched acetylthiomethylmalonate derivatives.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201400664