Effects of morphine on stress induced anxiety in rats: Role of nitric oxide and Hsp70

Abstract The present study evaluated the effects of morphine on acute and chronic restraint stress (RS) induced anxiety modulation and the possible involvement of nitric oxide (NO) and heat shock proteins (Hsp70) during such effects. Acute RS (× 1) induced anxiogenesis in the elevated plus maze (EPM...

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Bibliographic Details
Published in:Physiology & behavior 2015-02, Vol.139, p.393-396
Main Authors: Joshi, Jagdish C, Ray, Arunabha, Gulati, Kavita
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Anti-Anxiety Agents - pharmacology
Anxiety - drug therapy
Anxiety - physiopathology
Arginine - pharmacology
Brain - drug effects
Brain - physiopathology
Chronic Disease
Disease Models, Animal
Drug Synergism
Hsp70
HSP70 Heat-Shock Proteins - metabolism
l-Arginine
Male
Morphine
Morphine - pharmacology
Nitric oxide
Nitric Oxide - metabolism
Psychiatry
Rats, Wistar
Restraint, Physical
Stress
Stress, Psychological - drug therapy
Stress, Psychological - physiopathology
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Summary:Abstract The present study evaluated the effects of morphine on acute and chronic restraint stress (RS) induced anxiety modulation and the possible involvement of nitric oxide (NO) and heat shock proteins (Hsp70) during such effects. Acute RS (× 1) induced anxiogenesis in the elevated plus maze (EPM) test which was associated with lowered brain NO metabolites (NOx) and elevated Hsp70 levels. Pretreatment with morphine (1 and 5 mg/kg) and l -arginine (500 mg/kg) attenuated the RS effects on EPM activity and brain NOx, whereas, Hsp70 levels were further augmented. Co-administration of both agents showed synergistic effects. By contrast, repeated RS (× 15) did not induce any significant changes in EPM activity or brain NOx, but brain Hsp70 levels stayed elevated. Administration of morphine or l -arginine prior to chronic RS did not influence such chronic stress induced changes in behavioral and biochemical markers, but appreciably attenuated chronic RS induced elevation in Hsp70 levels. These results suggest that acute and chronic RS induced anxiety modulations were differentially influenced by morphine and l -arginine and that complex interactions involving brain NO and unregulated Hsp70 could regulate such effects.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2014.11.056