Influence of chemotherapy for lymphoma in canine parvovirus DNA distribution and specific humoral immunity

Abstract In man, the combination of cancer and its treatment increases patients’ susceptibility to opportunistic infections, due to immune system impairment. In veterinary medicine little information is available concerning this issue. In order to evaluate if a similar dysfunction is induced in smal...

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Bibliographic Details
Published in:Comparative immunology, microbiology and infectious diseases microbiology and infectious diseases, 2014-12, Vol.37 (5), p.313-320
Main Authors: Elias, M.A, Duarte, A, Nunes, T, Lourenço, A.M, Braz, B.S, Vicente, G, Henriques, J, Tavares, L
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies, Viral - blood
Antineoplastic Combined Chemotherapy Protocols
Canine lymphoma
Canine parvovirus
CHOP
Cyclophosphamide - administration & dosage
DNA, Viral - blood
Dog
Dogs
Doxorubicin - administration & dosage
Female
Humans
Immunity, Humoral - drug effects
Immunosuppression
Infectious Disease
Lymphoma - blood
Lymphoma - complications
Lymphoma - drug therapy
Lymphoma - immunology
Male
Parvoviridae Infections - blood
Parvoviridae Infections - complications
Parvoviridae Infections - immunology
Parvoviridae Infections - virology
Parvovirus, Canine - immunology
Parvovirus, Canine - pathogenicity
Prednisolone - administration & dosage
Prednisone
Species Specificity
Vincristine - administration & dosage
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Summary:Abstract In man, the combination of cancer and its treatment increases patients’ susceptibility to opportunistic infections, due to immune system impairment. In veterinary medicine little information is available concerning this issue. In order to evaluate if a similar dysfunction is induced in small animals undergoing chemotherapy, we assessed the complete blood count, leukocytic, plasma and fecal canine parvovirus (CPV) viral load, and anti-CPV protective antibody titers, in dogs with lymphoma treated with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) protocol, before and during chemotherapy. There was no evidence of decreased immune response, either at admission or after two chemotherapy cycles, indicating that the previously established immunity against CPV was not significantly impaired, supporting the idea that immunosuppression as a result of hematopoietic neoplasms and their treatment in dogs requires further investigation and conclusions cannot be extrapolated from human literature.
ISSN:0147-9571
1878-1667
DOI:10.1016/j.cimid.2014.09.005