Design of chitospheres loaded with pristine polymer particles for extended drug delivery via polyelectrolyte complexation and particulate leaching

[Display omitted] The aim of this study was to investigate the drug release from swellable chitospheres laden with pristine polymethylmethacrylate (PMMA) nanoparticles. Chitosan matrices were prepared by sodium tripolyphosphate crosslinking from a chitosan suspension containing the model BCS class I...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 2015-02, Vol.479 (1), p.189-206
Main Authors: Ramburrun, Poornima, Choonara, Yahya E., Kumar, Pradeep, du Toit, Lisa C., Pillay, Viness
Format: Article
Language:English
Subjects:
Chitosan
Chitosan - chemistry
Controlled drug release
Drug Delivery Systems
Drug Liberation
Drug release mechanisms
In situ leaching
Indomethacin - chemistry
Microscopy, Electron, Scanning
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Particle Size
Polyelectrolyte complex
Polymethyl methacrylate
Polymethyl Methacrylate - chemistry
Polyphosphates - chemistry
Porosity
Surface Properties
Thermogravimetry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] The aim of this study was to investigate the drug release from swellable chitospheres laden with pristine polymethylmethacrylate (PMMA) nanoparticles. Chitosan matrices were prepared by sodium tripolyphosphate crosslinking from a chitosan suspension containing the model BCS class II drug, indomethacin. PMMA particles were added to the chitospheres as the modulator for drug release. Swelling and erosion studies in conjunction with textural profiling provided an understanding of the dominant and underlying drug release mechanisms of the ionically crosslinked chitospheres loaded with the pristine PMMA particles. A series of drug release studies performed in PBS pH 7.4 showed that the pristine particle-loaded chitospheres released indomethacin over 144h in a first-order manner with 50% drug release occurring over 48h. The study also revealed that in situ porogen leaching for pore creation and polyelectrolyte complex formation were the main mechanisms of release from the chitospheres. The results of this study may be utilized for the development of neuro-implants for controlled delivery of bioactives to the brain where scaffolds of superior mechanical strength and reduced swelling properties are required.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2014.12.059