Age-related changes of leptin and leptin receptor variants in healthy elderly and long-lived adults

Aim Aging is usually associated with hyperleptinemia and leptin resistance, both increasing the risk of age‐related diseases. It was relevant to establish if healthily aging, non‐obese individuals develop changes in leptin, the soluble leptin receptor (OB‐Re), free leptin index (FLI), in methylation...

Full description

Saved in:
Bibliographic Details
Published in:Geriatrics & gerontology international 2015-03, Vol.15 (3), p.365-371
Main Authors: Roszkowska-Gancarz, Malgorzata, Jonas, Marta, Owczarz, Magdalena, Kurylowicz, Alina, Polosak, Jacek, Franek, Edward, Slusarczyk, Przemyslaw, Mossakowska, Malgorzata, Puzianowska-Kuznicka, Monika
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Aging
Aging - blood
Aging - genetics
Biomarkers - blood
Body Mass Index
Cross-Sectional Studies
DNA Methylation
Dyslipidemias - blood
Dyslipidemias - epidemiology
Dyslipidemias - genetics
Enzyme-Linked Immunosorbent Assay
Female
free leptin index
Gene Expression Regulation, Developmental
Geriatrics
healthy aging
Healthy Volunteers
Hormones
Humans
leptin
Leptin - biosynthesis
Leptin - genetics
leptin receptor isoforms
Male
Middle Aged
Poland - epidemiology
Prevalence
Prospective Studies
Receptors, Leptin - biosynthesis
Receptors, Leptin - genetics
Reverse Transcriptase Polymerase Chain Reaction
RNA - genetics
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim Aging is usually associated with hyperleptinemia and leptin resistance, both increasing the risk of age‐related diseases. It was relevant to establish if healthily aging, non‐obese individuals develop changes in leptin, the soluble leptin receptor (OB‐Re), free leptin index (FLI), in methylation of the leptin receptor gene (LEPR) promoter, and in the expression of long (OB‐Rb) and short (OB‐Ra) leptin receptor isoforms. Methods We analyzed these parameters in 38 young (aged 26.8 ± 3.6 years), 37 elderly (aged 64.7 ± 3.1 years) and 39 long‐lived (aged 94.2 ± 3.7 years) healthy, non‐obese Polish Caucasians. Results In elderly men, the median concentration of leptin and the median FLI were significantly higher than in young men (P = 0.009 and P = 0.007, respectively), which was probably partly due to a higher mean body mass index of the elderly study participants. In peripheral blood mononuclear cells, the expression of functionally active OB‐Rb did not depend on age or sex, whereas the expression of OB‐Ra was lower in the elderly and long‐lived groups than in the young group (P 
ISSN:1444-1586
1447-0594
DOI:10.1111/ggi.12267