Efficacy of Nebulised Budesonide versus Oral Prednisolone in Acute Severe Asthma

Objective To compare the efficacy of nebulised budesonide with that of oral prednisone in the treatment of acute severe asthma in children. Methods Children aged 5–12 y with acute exacerbation of bronchial asthma were included. The study (budesonide) group received budesonide respirator solution (80...

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Bibliographic Details
Published in:Indian journal of pediatrics 2015-04, Vol.82 (4), p.328-332
Main Authors: Arulparithi, Cuddalore Subramanian, Babu, Thirunavukkarasu Arun, Ravichandran, C., Santhanam, Indumathy, Sathyamurthi, B., Parivathini, S., Hemachitra, J.
Format: Article
Language:English
Subjects:
Bronchodilator Agents - administration & dosage
Budesonide - administration & dosage
Child
Double-Blind Method
Drug Monitoring - methods
Female
Glucocorticoids - administration & dosage
Gynecology
Humans
Male
Medicine
Medicine & Public Health
Nebulizers and Vaporizers
Original Article
Oxygen - analysis
Patient Acuity
Pediatrics
Prednisolone - administration & dosage
Respiratory Function Tests - methods
Status Asthmaticus - diagnosis
Status Asthmaticus - drug therapy
Status Asthmaticus - physiopathology
Treatment Outcome
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Summary:Objective To compare the efficacy of nebulised budesonide with that of oral prednisone in the treatment of acute severe asthma in children. Methods Children aged 5–12 y with acute exacerbation of bronchial asthma were included. The study (budesonide) group received budesonide respirator solution (800 μg) at intervals of 20 min and a single dose of placebo tablets. The control (prednisolone) group received placebo solution at intervals of 20 min and a single dose of oral prednisolone (2 mg/kg). Both groups received three doses of nebulised salbutamol (0.15 mg/kg). Heart rate, respiratory rate, oxygen saturation, PEFR (Peak Expiratory Flow Rate) and fitness for discharge were assessed. Results Both groups showed a progressive decrease in tachycardia with treatment, but it was significantly greater in study group ( p  = 0.0002). There was significant decrease in tachypnea and improvement in oxygen saturation in both groups, but the difference between the groups ( p  = 0.334 and p  = 0.814 respectively) was not significant. There was significant improvement in PEFR values in budesonide group ( p  = 0.024). Both groups showed significant improvement in clinical severity scores at the end of 2 h ( p  
ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-014-1498-0