Matrix Metalloproteinase-2 Mediates a Mechanism of Metabolic Cardioprotection Consisting of Negative Regulation of the Sterol Regulatory Element–Binding Protein-2/3-Hydroxy-3-Methylglutaryl-CoA Reductase Pathway in the Heart

Previously, we reported that cardiac matrix metalloproteinase (MMP)-2 is upregulated in hypertensive mice. How MMP-2 affects the development of cardiac disease is unclear. Here, we report that MMP-2 protects from hypertensive cardiac disease. In mice infused with angiotensin II, the lack of MMP-2 (M...

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Bibliographic Details
Published in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2015-04, Vol.65 (4), p.882-888
Main Authors:	Wang, Xiang, Berry, Evan, Hernandez-Anzaldo, Samuel, Takawale, Abhijit, Kassiri, Zamaneh, Fernandez-Patron, Carlos
Format:	Article
Language:	English
Subjects:	Acyl Coenzyme A - biosynthesis Acyl Coenzyme A - genetics Animals Blood Pressure Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - physiopathology Disease Models, Animal Gene Expression Regulation Immunoblotting Male Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Mice Mice, Inbred C57BL Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Real-Time Polymerase Chain Reaction RNA - genetics Sterol Regulatory Element Binding Protein 2 - biosynthesis Sterol Regulatory Element Binding Protein 2 - genetics Transcription Factors
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