Comparison of Antioxidant Effects of Isoflurane and Propofol in Patients Undergoing Donor Hepatectomy

• Published in: Transplantation proceedings 2015-03, Vol.47 (2), p.469-472
• Main Authors: Ucar, M, Ozgül, U, Polat, A, Toprak, H.I, Erdogan, M.A, Aydogan, M.S, Durmus, M, Ersoy, M.O
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Anesthesia - methods; Antioxidants - pharmacology; Antioxidants - therapeutic use; Biomarkers - blood; Female; Hepatectomy - adverse effects; Hepatectomy - methods; Humans; Isoflurane - pharmacology; Isoflurane - therapeutic use; Liver Transplantation; Living Donors; Male; Malondialdehyde - blood; Middle Aged; Oxidative Stress - drug effects; Postoperative Period; Preoperative Period; Propofol - pharmacology; Propofol - therapeutic use; Reperfusion Injury - etiology; Reperfusion Injury - metabolism; Reperfusion Injury - prevention & control; Superoxide Dismutase - blood; Surgery; Tissue and Organ Harvesting - adverse effects; Tissue and Organ Harvesting - methods; Young Adult
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2014.11.043

Abstract Background The safety of healthy volunteer donors is one of the most important issues in living-donor liver transplantation. Use of the Pringle maneuver during donor hepatectomy can result in liver ischemia-reperfusion (IR) injury. The objective of this study was to examine the effects of isoflurane and propofol on IR injury caused by the Pringle maneuver during donor hepatectomy. Methods A total of 70 American Society of Anesthesiology I-II donors aged 18–65 years who underwent hepatectomy were included in the study. The patients were randomly divided into 2 groups: propofol and isoflurane. Plasma superoxide dismutase (SOD), malondialdehyde (MDA), total oxidative status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) were measured before surgery (t0 ) and after surgery (t1 ). Results There were no statistically significant differences in demographic features, anesthesia, and times of surgery between the groups ( P > .05). Plasma TAC levels at t0 and t1 were significantly lower in the propofol group than in the isoflurane group ( P  < .05). OSI at t1 was significantly higher in the propofol group than in the isoflurane group ( P  < .05). MDA levels were significantly higher in the propofol group than in the isoflurane group at t0 ( P  < .05). MDA levels level were significantly higher in the isoflurane group than in the propofol group at t1 ( P  < .05). Conclusions Propofol may have protective effects against IR injury caused by the Pringle maneuver during donor hepatectomy in living-donor transplantations. However, the effectiveness of propofol for clinical use needs to be investigated further.