Effects of a short-term reduction in brain serotonin synthesis on the availability of the soluble leptin receptor in healthy women

Serotonin (5-HT) and the hormone leptin have been linked to the underlying neurobiology of appetite regulation with evidence coming from animal and cellular research, but direct evidence linking these two pathways in humans is lacking. We examined the effects of reduced brain 5-HT synthesis due to a...

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Bibliographic Details
Published in:Journal of Neural Transmission 2015-03, Vol.122 (3), p.343-348
Main Authors: Zepf, F. D., Dingerkus, V. L. S., Helmbold, K., Bubenzer-Busch, S., Biskup, C. S., Herpertz-Dahlmann, B., Schaab, M., Kratzsch, J., Eisert, A., Rink, L., Hagenah, U., Gaber, T. J.
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Brain - metabolism
Cohort Studies
Double-Blind Method
Female
Food, Formulated
Humans
Leptin - blood
Male
Medicine
Medicine & Public Health
Neurology
Neurosciences
Psychiatry
Receptors, Leptin - metabolism
Serotonin - metabolism
Time Factors
Translational Neurosciences - Original Article
Tryptophan - deficiency
Young Adult
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Summary:Serotonin (5-HT) and the hormone leptin have been linked to the underlying neurobiology of appetite regulation with evidence coming from animal and cellular research, but direct evidence linking these two pathways in humans is lacking. We examined the effects of reduced brain 5-HT synthesis due to acute tryptophan depletion (ATD) on levels of soluble leptin receptor (sOb-R), the main high-affinity leptin binding protein, in healthy adults using an exploratory approach. Women, but not men, showed reduced sOb-R concentrations after ATD administration. With females showing reduced baseline levels of central 5-HT synthesis compared to males diminished brain 5-HT synthesis affected the leptin axis through the sOb-R in females, thereby potentially influencing their vulnerability to dysfunctional appetite regulation and co-morbid mood symptoms.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-014-1292-1