Sedentary behaviour patterns and carotid intima-media thickness in Spanish healthy adult population

Abstract Objective The aim of this study was to analyze the association between sedentary behaviour, as assessed by an accelerometer, and mean carotid intima-media thickness (IMT). Methods The study included 263 healthy subjects belonging to the EVIDENT study (59.3% women). Carotid IMT was measured...

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Bibliographic Details
Published in:Atherosclerosis 2015-04, Vol.239 (2), p.571-576
Main Authors: García-Hermoso, Antonio, Martínez-Vizcaíno, Vicente, Recio-Rodríguez, José Ignacio, Sánchez-López, Mairena, Gómez-Marcos, Manuel Ángel, García-Ortiz, Luis
Format: Article
Language:English
Subjects:
Accelerometer
Actigraphy
Adult
Aged
Atherosclerosis
Cardiovascular
Cardiovascular risk factor
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - etiology
Carotid Intima-Media Thickness
Cross-Sectional Studies
Female
Healthy Volunteers
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Predictive Value of Tests
Risk Factors
Sedentary
Sedentary Lifestyle
Spain
Time Factors
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Summary:Abstract Objective The aim of this study was to analyze the association between sedentary behaviour, as assessed by an accelerometer, and mean carotid intima-media thickness (IMT). Methods The study included 263 healthy subjects belonging to the EVIDENT study (59.3% women). Carotid IMT was measured by carotid ultrasonography. Sedentary behaviour was measured objectively over 7 days using ActiGraph accelerometers. Thresholds of 10 consecutive minutes were used to establish sedentary bouts, and assess the number (n/day), and length ≥10 min (min/day). Results Total sedentary time and sedentary time in bouts ≥10 min was higher in participants with a larger mean carotid IMT (>P75). Otherwise, this sedentary time in bouts ≥10 min parameter was weakly associated with augmented carotid IMT injury in the logistic regression model. Conclusion Total sedentary time and sedentary time in bouts ≥10 min, as assessed by accelerometer, was positively but weakly associated with carotid IMT. Equally, this sedentary time in bouts ≥10 min was associated with carotid injury, but disappears after adjusting for potential confounders. These findings support that reducing sedentary time and increasing breaks in bouts of sedentary time might represent a useful additional strategy in the cardiovascular disease prevention. Trial Registration Clinical Trials.gov Identifier: NCT01083082.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2015.02.028