Lipotoxicity and the role of maternal nutrition

Intrauterine malnutrition predisposes the offspring towards the development of type 2 diabetes and cardiovascular disease. To explain this association, the Developmental Origins of Health and Disease hypothesis was introduced, meaning that subtle environmental changes during embryonic and foetal dev...

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Bibliographic Details
Published in:Acta Physiologica 2014-02, Vol.210 (2), p.296-306
Main Authors: Pruis, M. G. M., van Ewijk, P. A., Schrauwen-Hinderling, V. B., Plösch, T.
Format: Article
Language:English
Subjects:
Animals
Epigenetics
Female
Fetal Development - physiology
Fetal Nutrition Disorders
foetal programming
heart failure
Humans
Lipids - toxicity
lipotoxicity
Metabolic Syndrome - embryology
non-alcoholic steatohepatitis
obesity
Pregnancy
Prenatal Exposure Delayed Effects - physiopathology
Prenatal Nutritional Physiological Phenomena - physiology
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Summary:Intrauterine malnutrition predisposes the offspring towards the development of type 2 diabetes and cardiovascular disease. To explain this association, the Developmental Origins of Health and Disease hypothesis was introduced, meaning that subtle environmental changes during embryonic and foetal development can influence post‐natal physiological functions. Different mechanisms, including epigenetics, are thought to be involved in this foetal programming, but the link between epigenetics and disease is missing. There is increasing evidence that ectopic lipid accumulation and/or lipotoxicity is induced by foetal programming. The aim of this review is to provide insights into the mechanisms underlying lipotoxicity through programming, which contributes to the increase in hepatic and cardiac metabolic risk.
ISSN:1748-1708
1748-1716
DOI:10.1111/apha.12171